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dc.contributor.authorMichailidou, K
dc.contributor.authorLindström, S
dc.contributor.authorDennis, J
dc.contributor.authorBeesley, J
dc.contributor.authorHui, S
dc.contributor.authorKar, S
dc.contributor.authorLemaçon, A
dc.contributor.authorSoucy, P
dc.contributor.authorGlubb, D
dc.contributor.authorRostamianfar, A
dc.contributor.authorBolla, MK
dc.contributor.authorWang, Q
dc.contributor.authorTyrer, J
dc.contributor.authorDicks, E
dc.contributor.authorLee, A
dc.contributor.authorWang, Z
dc.contributor.authorAllen, J
dc.contributor.authorKeeman, R
dc.contributor.authorEilber, U
dc.contributor.authorFrench, JD
dc.contributor.authorQing Chen, X
dc.contributor.authorFachal, L
dc.contributor.authorMcCue, K
dc.contributor.authorMcCart Reed, AE
dc.contributor.authorGhoussaini, M
dc.contributor.authorCarroll, JS
dc.contributor.authorJiang, X
dc.contributor.authorFinucane, H
dc.contributor.authorAdams, M
dc.contributor.authorAdank, MA
dc.contributor.authorAhsan, H
dc.contributor.authorAittomäki, K
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntonenkova, NN
dc.contributor.authorArndt, V
dc.contributor.authorAronson, KJ
dc.contributor.authorArun, B
dc.contributor.authorAuer, PL
dc.contributor.authorBacot, F
dc.contributor.authorBarrdahl, M
dc.contributor.authorBaynes, C
dc.contributor.authorBeckmann, MW
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBernstein, L
dc.contributor.authorBlomqvist, C
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBonanni, B
dc.contributor.authorBørresen-Dale, A-L
dc.contributor.authorBrand, JS
dc.contributor.authorBrauch, H
dc.contributor.authorBrennan, P
dc.contributor.authorBrenner, H
dc.contributor.authorBrinton, L
dc.contributor.authorBroberg, P
dc.contributor.authorBrock, IW
dc.contributor.authorBroeks, A
dc.contributor.authorBrooks-Wilson, A
dc.contributor.authorBrucker, SY
dc.contributor.authorBrüning, T
dc.contributor.authorBurwinkel, B
dc.contributor.authorButterbach, K
dc.contributor.authorCai, Q
dc.contributor.authorCai, H
dc.contributor.authorCaldés, T
dc.contributor.authorCanzian, F
dc.contributor.authorCarracedo, A
dc.contributor.authorCarter, BD
dc.contributor.authorCastelao, JE
dc.contributor.authorChan, TL
dc.contributor.authorDavid Cheng, T-Y
dc.contributor.authorSeng Chia, K
dc.contributor.authorChoi, J-Y
dc.contributor.authorChristiansen, H
dc.contributor.authorClarke, CL
dc.contributor.authorNBCS Collaborators
dc.contributor.authorCollée, M
dc.contributor.authorConroy, DM
dc.contributor.authorCordina-Duverger, E
dc.contributor.authorCornelissen, S
dc.contributor.authorCox, DG
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCunningham, JM
dc.contributor.authorCzene, K
dc.contributor.authorDaly, MB
dc.contributor.authorDevilee, P
dc.contributor.authorDoheny, KF
dc.contributor.authorDörk, T
dc.contributor.authorDos-Santos-Silva, I
dc.contributor.authorDumont, M
dc.contributor.authorDurcan, L
dc.contributor.authorDwek, M
dc.contributor.authorEccles, DM
dc.contributor.authorEkici, AB
dc.contributor.authorEliassen, AH
dc.contributor.authorEllberg, C
dc.contributor.authorElvira, M
dc.contributor.authorEngel, C
dc.contributor.authorEriksson, M
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFlesch-Janys, D
dc.contributor.authorFletcher, O
dc.contributor.authorFlyger, H
dc.contributor.authorFritschi, L
dc.contributor.authorGaborieau, V
dc.contributor.authorGabrielson, M
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGao, Y-T
dc.contributor.authorGapstur, SM
dc.contributor.authorGarcía-Sáenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGeorgoulias, V
dc.contributor.authorGiles, GG
dc.contributor.authorGlendon, G
dc.contributor.authorGoldberg, MS
dc.contributor.authorGoldgar, DE
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorGrenaker Alnæs, GI
dc.contributor.authorGrip, M
dc.contributor.authorGronwald, J
dc.contributor.authorGrundy, A
dc.contributor.authorGuénel, P
dc.contributor.authorHaeberle, L
dc.contributor.authorHahnen, E
dc.contributor.authorHaiman, CA
dc.contributor.authorHåkansson, N
dc.contributor.authorHamann, U
dc.contributor.authorHamel, N
dc.contributor.authorHankinson, S
dc.contributor.authorHarrington, P
dc.contributor.authorHart, SN
dc.contributor.authorHartikainen, JM
dc.contributor.authorHartman, M
dc.contributor.authorHein, A
dc.contributor.authorHeyworth, J
dc.contributor.authorHicks, B
dc.contributor.authorHillemanns, P
dc.contributor.authorHo, DN
dc.contributor.authorHollestelle, A
dc.contributor.authorHooning, MJ
dc.contributor.authorHoover, RN
dc.contributor.authorHopper, JL
dc.contributor.authorHou, M-F
dc.contributor.authorHsiung, C-N
dc.contributor.authorHuang, G
dc.contributor.authorHumphreys, K
dc.contributor.authorIshiguro, J
dc.contributor.authorIto, H
dc.contributor.authorIwasaki, M
dc.contributor.authorIwata, H
dc.contributor.authorJakubowska, A
dc.contributor.authorJanni, W
dc.contributor.authorJohn, EM
dc.contributor.authorJohnson, N
dc.contributor.authorJones, K
dc.contributor.authorJones, M
dc.contributor.authorJukkola-Vuorinen, A
dc.contributor.authorKaaks, R
dc.contributor.authorKabisch, M
dc.contributor.authorKaczmarek, K
dc.contributor.authorKang, D
dc.contributor.authorKasuga, Y
dc.contributor.authorKerin, MJ
dc.contributor.authorKhan, S
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKiiski, JI
dc.contributor.authorKim, S-W
dc.contributor.authorKnight, JA
dc.contributor.authorKosma, V-M
dc.contributor.authorKristensen, VN
dc.contributor.authorKrüger, U
dc.contributor.authorKwong, A
dc.contributor.authorLambrechts, D
dc.contributor.authorLe Marchand, L
dc.contributor.authorLee, E
dc.contributor.authorLee, MH
dc.contributor.authorLee, JW
dc.contributor.authorNeng Lee, C
dc.contributor.authorLejbkowicz, F
dc.contributor.authorLi, J
dc.contributor.authorLilyquist, J
dc.contributor.authorLindblom, A
dc.contributor.authorLissowska, J
dc.contributor.authorLo, W-Y
dc.contributor.authorLoibl, S
dc.contributor.authorLong, J
dc.contributor.authorLophatananon, A
dc.contributor.authorLubinski, J
dc.contributor.authorLuccarini, C
dc.contributor.authorLux, MP
dc.contributor.authorMa, ESK
dc.contributor.authorMacInnis, RJ
dc.contributor.authorMaishman, T
dc.contributor.authorMakalic, E
dc.contributor.authorMalone, KE
dc.contributor.authorKostovska, IM
dc.contributor.authorMannermaa, A
dc.contributor.authorManoukian, S
dc.contributor.authorManson, JE
dc.contributor.authorMargolin, S
dc.contributor.authorMariapun, S
dc.contributor.authorMartinez, ME
dc.contributor.authorMatsuo, K
dc.contributor.authorMavroudis, D
dc.contributor.authorMcKay, J
dc.contributor.authorMcLean, C
dc.contributor.authorMeijers-Heijboer, H
dc.contributor.authorMeindl, A
dc.contributor.authorMenéndez, P
dc.contributor.authorMenon, U
dc.contributor.authorMeyer, J
dc.contributor.authorMiao, H
dc.contributor.authorMiller, N
dc.contributor.authorTaib, NAM
dc.contributor.authorMuir, K
dc.contributor.authorMulligan, AM
dc.contributor.authorMulot, C
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNeven, P
dc.contributor.authorNielsen, SF
dc.contributor.authorNoh, D-Y
dc.contributor.authorNordestgaard, BG
dc.contributor.authorNorman, A
dc.contributor.authorOlopade, OI
dc.contributor.authorOlson, JE
dc.contributor.authorOlsson, H
dc.contributor.authorOlswold, C
dc.contributor.authorOrr, N
dc.contributor.authorPankratz, VS
dc.contributor.authorPark, SK
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorLloyd, R
dc.contributor.authorPerez, JIA
dc.contributor.authorPeterlongo, P
dc.contributor.authorPeto, J
dc.contributor.authorPhillips, K-A
dc.contributor.authorPinchev, M
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPrentice, R
dc.contributor.authorPresneau, N
dc.contributor.authorProkofyeva, D
dc.contributor.authorPugh, E
dc.contributor.authorPylkäs, K
dc.contributor.authorRack, B
dc.contributor.authorRadice, P
dc.contributor.authorRahman, N
dc.contributor.authorRennert, G
dc.contributor.authorRennert, HS
dc.contributor.authorRhenius, V
dc.contributor.authorRomero, A
dc.contributor.authorRomm, J
dc.contributor.authorRuddy, KJ
dc.contributor.authorRüdiger, T
dc.contributor.authorRudolph, A
dc.contributor.authorRuebner, M
dc.contributor.authorRutgers, EJT
dc.contributor.authorSaloustros, E
dc.contributor.authorSandler, DP
dc.contributor.authorSangrajrang, S
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmidt, DF
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSchneeweiss, A
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorSchumacher, F
dc.contributor.authorSchürmann, P
dc.contributor.authorScott, RJ
dc.contributor.authorScott, C
dc.contributor.authorSeal, S
dc.contributor.authorSeynaeve, C
dc.contributor.authorShah, M
dc.contributor.authorSharma, P
dc.contributor.authorShen, C-Y
dc.contributor.authorSheng, G
dc.contributor.authorSherman, ME
dc.contributor.authorShrubsole, MJ
dc.contributor.authorShu, X-O
dc.contributor.authorSmeets, A
dc.contributor.authorSohn, C
dc.contributor.authorSouthey, MC
dc.contributor.authorSpinelli, JJ
dc.contributor.authorStegmaier, C
dc.contributor.authorStewart-Brown, S
dc.contributor.authorStone, J
dc.contributor.authorStram, DO
dc.contributor.authorSurowy, H
dc.contributor.authorSwerdlow, A
dc.contributor.authorTamimi, R
dc.contributor.authorTaylor, JA
dc.contributor.authorTengström, M
dc.contributor.authorTeo, SH
dc.contributor.authorBeth Terry, M
dc.contributor.authorTessier, DC
dc.contributor.authorThanasitthichai, S
dc.contributor.authorThöne, K
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTomlinson, I
dc.contributor.authorTong, L
dc.contributor.authorTorres, D
dc.contributor.authorTruong, T
dc.contributor.authorTseng, C-C
dc.contributor.authorTsugane, S
dc.contributor.authorUlmer, H-U
dc.contributor.authorUrsin, G
dc.contributor.authorUntch, M
dc.contributor.authorVachon, C
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorVan Den Berg, D
dc.contributor.authorvan den Ouweland, AMW
dc.contributor.authorvan der Kolk, L
dc.contributor.authorvan der Luijt, RB
dc.contributor.authorVincent, D
dc.contributor.authorVollenweider, J
dc.contributor.authorWaisfisz, Q
dc.contributor.authorWang-Gohrke, S
dc.contributor.authorWeinberg, CR
dc.contributor.authorWendt, C
dc.contributor.authorWhittemore, AS
dc.contributor.authorWildiers, H
dc.contributor.authorWillett, W
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorWu, AH
dc.contributor.authorXia, L
dc.contributor.authorYamaji, T
dc.contributor.authorYang, XR
dc.contributor.authorHar Yip, C
dc.contributor.authorYoo, K-Y
dc.contributor.authorYu, J-C
dc.contributor.authorZheng, W
dc.contributor.authorZheng, Y
dc.contributor.authorZhu, B
dc.contributor.authorZiogas, A
dc.contributor.authorZiv, E
dc.contributor.authorABCTB Investigators
dc.contributor.authorConFab/AOCS Investigators
dc.contributor.authorLakhani, SR
dc.contributor.authorAntoniou, AC
dc.contributor.authorDroit, A
dc.contributor.authorAndrulis, IL
dc.contributor.authorAmos, CI
dc.contributor.authorCouch, FJ
dc.contributor.authorPharoah, PDP
dc.contributor.authorChang-Claude, J
dc.contributor.authorHall, P
dc.contributor.authorHunter, DJ
dc.contributor.authorMilne, RL
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorSchmidt, MK
dc.contributor.authorChanock, SJ
dc.contributor.authorDunning, AM
dc.contributor.authorEdwards, SL
dc.contributor.authorBader, GD
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorSimard, J
dc.contributor.authorKraft, P
dc.contributor.authorEaston, DF
dc.date.accessioned2018-07-11T15:23:24Z
dc.date.issued2017-11
dc.identifier.citationNature, 2017, 551 (7678), pp. 92 - 94
dc.identifier.issn0028-0836
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2042
dc.identifier.eissn1476-4687
dc.identifier.doi10.1038/nature24284
dc.description.abstractBreast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10 -8 . The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.
dc.formatPrint-Electronic
dc.format.extent92 - 94
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectNBCS Collaborators
dc.subjectABCTB Investigators
dc.subjectConFab/AOCS Investigators
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectTranscription Factors
dc.subjectRisk Assessment
dc.subjectBinding Sites
dc.subjectRegulatory Sequences, Nucleic Acid
dc.subjectMultifactorial Inheritance
dc.subjectPolymorphism, Single Nucleotide
dc.subjectComputer Simulation
dc.subjectAsian Continental Ancestry Group
dc.subjectEuropean Continental Ancestry Group
dc.subjectAsia
dc.subjectEurope
dc.subjectFemale
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.titleAssociation analysis identifies 65 new breast cancer risk loci.
dc.typeJournal Article
dcterms.dateAccepted2017-09-17
rioxxterms.versionofrecord10.1038/nature24284
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature
pubs.issue7678
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume551
pubs.embargo.termsNot known
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorFletcher, Oliviaen
dc.contributor.icrauthorOrr, Nicholasen
dc.contributor.icrauthorSchoemaker, Minouken
dc.contributor.icrauthorJones, Michaelen
dc.contributor.icrauthorSwerdlow, Anthonyen


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