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dc.contributor.authorDi Martino, MT
dc.contributor.authorGuzzi, PH
dc.contributor.authorCaracciolo, D
dc.contributor.authorAgnelli, L
dc.contributor.authorNeri, A
dc.contributor.authorWalker, BA
dc.contributor.authorMorgan, GJ
dc.contributor.authorCannataro, M
dc.contributor.authorTassone, P
dc.contributor.authorTagliaferri, P
dc.date.accessioned2018-07-16T10:30:03Z
dc.date.issued2015-08-07
dc.identifier.citationOncotarget, 2015, 6 (22), pp. 19132 - 19147
dc.identifier.issn1949-2553
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2074
dc.identifier.eissn1949-2553
dc.identifier.doi10.18632/oncotarget.4302
dc.description.abstractMultiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HD-MM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT)3 pathway as well as the Transforming Growth Factor-beta (TGFβ) and the transcription regulator Nuclear Protein-1 (NUPR1). Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets.
dc.formatPrint
dc.format.extent19132 - 19147
dc.languageeng
dc.language.isoeng
dc.publisherIMPACT JOURNALS LLC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectMultiple Myeloma
dc.subjectTranscription Factors
dc.subjectMicroRNAs
dc.subjectRNA, Messenger
dc.subjectGene Expression
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectDiploidy
dc.subjectModels, Genetic
dc.titleIntegrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma.
dc.typeJournal Article
dcterms.dateAccepted2015-05-13
rioxxterms.versionofrecord10.18632/oncotarget.4302
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2015-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfOncotarget
pubs.issue22
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.publication-statusPublished
pubs.volume6
pubs.embargo.termsNot known
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)
dc.contributor.icrauthorWalker, Brian Andrew


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