Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma
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Multiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HDMM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT) 3 pathway as well as the Transforming Growth Factor-beta (TGF beta) and the transcription regulator Nuclear Protein-1 (NUPR1). Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets.
integromics microRNA miRNA transcription factors multiple myeloma hyperdiploid myeloma VIVO ANTITUMOR-ACTIVITY IN-VITRO TGF-BETA ENDOTHELIAL-CELLS STAT INHIBITORS BONE-DISEASE CANCER SIGNATURES ACTIVATION MECHANISMS Oncology Cell Biology
Molecular Haematology (including Cytogenetics Group and Cell Markers)
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Oncotarget, 2015, 6 (22), pp. 19132 - 19147