Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma.
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Date
2015-08-07ICR Author
Author
Di Martino, MT
Guzzi, PH
Caracciolo, D
Agnelli, L
Neri, A
Walker, BA
Morgan, GJ
Cannataro, M
Tassone, P
Tagliaferri, P
Type
Journal Article
Metadata
Show full item recordAbstract
Multiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HD-MM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT)3 pathway as well as the Transforming Growth Factor-beta (TGFβ) and the transcription regulator Nuclear Protein-1 (NUPR1). Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets.
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Subject
Humans
Multiple Myeloma
Transcription Factors
MicroRNAs
RNA, Messenger
Gene Expression
Gene Expression Regulation, Neoplastic
Diploidy
Models, Genetic
Research team
Molecular Haematology (including Cytogenetics Group and Cell Markers)
Language
eng
Date accepted
2015-05-13
License start date
2015-08
Citation
Oncotarget, 2015, 6 (22), pp. 19132 - 19147
Publisher
IMPACT JOURNALS LLC