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dc.contributor.authorReis-Filho, J
dc.date.accessioned2018-08-13T10:19:20Z
dc.date.issued2012
dc.identifierhttp://breast-cancer-research.com/content/14/3/313
dc.identifier.citationBREAST CANCER RESEARCH, 2012, 14 (3)
dc.identifier.issn1465-5411
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2314
dc.description.abstractTesting the statistical associations between microarray-based gene expression signatures and patient outcome has become a popular approach to infer biological and clinical significance of laboratory observations. Venet and colleagues recently demonstrated that the majority of randomly generated gene signatures are significantly associated with outcome of breast cancer patients, and that this association stems from the fact that a large proportion of the transcriptome is significantly correlated with proliferation, a strong predictor of outcome in breast cancer patients. These findings demonstrate that a statistical association between a gene signature and disease outcome does not necessarily imply biological significance.
dc.languageeng
dc.language.isoeng
dc.subjectmolecular portraits classification prediction tumors
dc.titlePrognostic signatures in breast cancer: correlation does not imply causation
dc.typeJournal Article
rioxxterms.licenseref.startdate2012
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBREAST CANCER RESEARCH
pubs.issue3
pubs.notesISI Document Delivery No.: 036AI Times Cited: 0 Cited Reference Count: 14 Ng, Charlotte Weigelt, Britta Grigoriadis, Anita Reis-Filho, Jorge S. Breakthrough Breast Cancer; Cancer Research UK postdoctoral fellowship; NHS The authors' work is supported by Breakthrough Breast Cancer. BW is funded by a Cancer Research UK postdoctoral fellowship. The authors acknowledge NHS funding for the NIHR Biomedical Research Centre. Biomed central ltd London
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology
pubs.volume14en_US
pubs.embargo.termsNot known
icr.researchteamMolecular Pathologyen_US
dc.contributor.icrauthorReis-Filho, Jorge Sergioen


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