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dc.contributor.authorO'Mara, TA
dc.contributor.authorGlubb, DM
dc.contributor.authorAmant, F
dc.contributor.authorAnnibali, D
dc.contributor.authorAshton, K
dc.contributor.authorAttia, J
dc.contributor.authorAuer, PL
dc.contributor.authorBeckmann, MW
dc.contributor.authorBlack, A
dc.contributor.authorBolla, MK
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrinton, L
dc.contributor.authorBuchanan, DD
dc.contributor.authorBurwinkel, B
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, SJ
dc.contributor.authorChen, C
dc.contributor.authorChen, MM
dc.contributor.authorCheng, THT
dc.contributor.authorClarke, CL
dc.contributor.authorClendenning, M
dc.contributor.authorCook, LS
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCrous-Bous, M
dc.contributor.authorCzene, K
dc.contributor.authorDay, F
dc.contributor.authorDennis, J
dc.contributor.authorDepreeuw, J
dc.contributor.authorDoherty, JA
dc.contributor.authorDörk, T
dc.contributor.authorDowdy, SC
dc.contributor.authorDürst, M
dc.contributor.authorEkici, AB
dc.contributor.authorFasching, PA
dc.contributor.authorFridley, BL
dc.contributor.authorFriedenreich, CM
dc.contributor.authorFritschi, L
dc.contributor.authorFung, J
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGaudet, MM
dc.contributor.authorGiles, GG
dc.contributor.authorGoode, EL
dc.contributor.authorGorman, M
dc.contributor.authorHaiman, CA
dc.contributor.authorHall, P
dc.contributor.authorHankison, SE
dc.contributor.authorHealey, CS
dc.contributor.authorHein, A
dc.contributor.authorHillemanns, P
dc.contributor.authorHodgson, S
dc.contributor.authorHoivik, EA
dc.contributor.authorHolliday, EG
dc.contributor.authorHopper, JL
dc.contributor.authorHunter, DJ
dc.contributor.authorJones, A
dc.contributor.authorKrakstad, C
dc.contributor.authorKristensen, VN
dc.contributor.authorLambrechts, D
dc.contributor.authorMarchand, LL
dc.contributor.authorLiang, X
dc.contributor.authorLindblom, A
dc.contributor.authorLissowska, J
dc.contributor.authorLong, J
dc.contributor.authorLu, L
dc.contributor.authorMagliocco, AM
dc.contributor.authorMartin, L
dc.contributor.authorMcEvoy, M
dc.contributor.authorMeindl, A
dc.contributor.authorMichailidou, K
dc.contributor.authorMilne, RL
dc.contributor.authorMints, M
dc.contributor.authorMontgomery, GW
dc.contributor.authorNassir, R
dc.contributor.authorOlsson, H
dc.contributor.authorOrlow, I
dc.contributor.authorOtton, G
dc.contributor.authorPalles, C
dc.contributor.authorPerry, JRB
dc.contributor.authorPeto, J
dc.contributor.authorPooler, L
dc.contributor.authorPrescott, J
dc.contributor.authorProietto, T
dc.contributor.authorRebbeck, TR
dc.contributor.authorRisch, HA
dc.contributor.authorRogers, PAW
dc.contributor.authorRübner, M
dc.contributor.authorRunnebaum, I
dc.contributor.authorSacerdote, C
dc.contributor.authorSarto, GE
dc.contributor.authorSchumacher, F
dc.contributor.authorScott, RJ
dc.contributor.authorSetiawan, VW
dc.contributor.authorShah, M
dc.contributor.authorSheng, X
dc.contributor.authorShu, X-O
dc.contributor.authorSouthey, MC
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTham, E
dc.contributor.authorTrovik, J
dc.contributor.authorTurman, C
dc.contributor.authorTyrer, JP
dc.contributor.authorVachon, C
dc.contributor.authorVanDen Berg, D
dc.contributor.authorVanderstichele, A
dc.contributor.authorWang, Z
dc.contributor.authorWebb, PM
dc.contributor.authorWentzensen, N
dc.contributor.authorWerner, HMJ
dc.contributor.authorWinham, SJ
dc.contributor.authorWolk, A
dc.contributor.authorXia, L
dc.contributor.authorXiang, Y-B
dc.contributor.authorYang, HP
dc.contributor.authorYu, H
dc.contributor.authorZheng, W
dc.contributor.authorPharoah, PDP
dc.contributor.authorDunning, AM
dc.contributor.authorKraft, P
dc.contributor.authorDe Vivo, I
dc.contributor.authorTomlinson, I
dc.contributor.authorEaston, DF
dc.contributor.authorSpurdle, AB
dc.contributor.authorThompson, DJ
dc.date.accessioned2018-08-29T08:38:19Z
dc.date.issued2018-08-09
dc.identifier.citationNature communications, 2018, 9 (1), pp. 3166 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2393
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-018-05427-7
dc.description.abstractEndometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
dc.formatElectronic
dc.format.extent3166 - ?
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectChromatin
dc.subjectHumans
dc.subjectEndometrial Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Factors
dc.subjectSignal Transduction
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectQuantitative Trait Loci
dc.subjectFemale
dc.subjectGenome-Wide Association Study
dc.subjectBiomarkers, Tumor
dc.titleIdentification of nine new susceptibility loci for endometrial cancer.
dc.typeJournal Article
dcterms.dateAccepted2018-07-02
rioxxterms.versionofrecord10.1038/s41467-018-05427-7
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-08-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume9
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiology
dc.contributor.icrauthorSwerdlow, Anthony


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