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dc.contributor.authorMacafee, DAL
dc.contributor.authorWaller, M
dc.contributor.authorWhynes, DK
dc.contributor.authorMoss, S
dc.contributor.authorScholefield, JH
dc.date.accessioned2018-08-30T13:50:51Z
dc.date.issued2008-12-09
dc.identifier12
dc.identifier.citationBRITISH JOURNAL OF CANCER, 2008, 99 pp. 1991 - 2000
dc.identifier.issn0007-0920
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2468
dc.identifier.doi10.1038/sj.bjc.6604788
dc.description.abstractPopulation screening for colorectal cancer (CRC) has recently commenced in the United Kingdom supported by the evidence of a number of randomised trials and pilot studies. Certain factors are known to influence screening cost-effectiveness (e. g. compliance), but it remains unclear whether an ageing population (i.e. demographic change) might also have an effect. The aim of this study was to simulate a population-based screening setting using a Markov model and assess the effect of increasing life expectancy on CRC screening cost-effectiveness. A Markov model was constructed that aimed, using a cohort simulation, to estimate the cost-effectiveness of CRC screening in an England and Wales population for two timescales: 2003 (early cohort) and 2033 (late cohort). Four model outcomes were calculated; screened and non-screened cohorts in 2003 and 2033. The screened cohort of men and women aged 60 years were offered biennial unhydrated faecal occult blood testing until the age of 69 years. Life expectancy was assumed to increase by 2.5 years per decade. There were 407 552 fewer people entering the model in the 2033 model due to a lower birth cohort, and population screening saw 30 345 fewer CRC-related deaths over the 50 years of the model. Screening the 2033 cohort cost 96 pound million with cost savings of 43 pound million in terms of detection and treatment and 28 pound million in palliative care costs. After 30 years of follow-up, the cost per life year saved was 1544 pound. An identical screening programme in an early cohort (2003) saw a cost per life year saved of 1651 pound. Population screening for CRC is costly but enables cost savings in certain areas and a considerable reduction in mortality from CRC. This Markov simulation suggests that the cost-effectiveness of population screening for CRC in the United Kingdom may actually be improved by rising life expectancies.
dc.format.extent1991 - 2000
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.titlePopulation screening for colorectal cancer: the implications of an ageing population
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/sj.bjc.6604788
rioxxterms.licenseref.startdate2008-12-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBRITISH JOURNAL OF CANCER
pubs.notesaffiliation: Macafee, DAL (Reprint Author), Royal Victoria Infirm, Dept Surg, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England. Macafee, D. A. L., Royal Victoria Infirm, Dept Surg, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England. Whynes, D. K., Univ Nottingham, Sch Econ, Nottingham NG7 2RD, England. Waller, M.; Moss, S., Inst Canc Res, Surrey, England. Scholefield, J. H., Univ Nottingham Hosp, Queens Med Ctr, Wolfson Digest Dis Ctr, Div Gastrointestinal Surg, Nottingham NG7 2UH, England. keywords: colorectal cancer; modelling; economics; life expectancy keywords-plus: FECAL-OCCULT-BLOOD; RANDOMIZED CONTROLLED TRIAL; GENERAL-POPULATION; FOLLOW-UP; CARCINOMA; LIFE; MORTALITY research-areas: Oncology web-of-science-categories: Oncology author-email: [email protected] researcherid-numbers: Waller, Michael/R-6231-2016 orcid-numbers: Waller, Michael/0000-0002-1050-4574 number-of-cited-references: 38 times-cited: 17 usage-count-last-180-days: 0 usage-count-since-2013: 1 journal-iso: Br. J. Cancer doc-delivery-number: 382QI unique-id: ISI:000261620100005 oa: gold_or_bronze da: 2018-08-30
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Cancer Screening Evaluation Unit (DoH)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Cancer Screening Evaluation Unit (DoH)
pubs.volume99
pubs.embargo.termsNot known
icr.researchteamCancer Screening Evaluation Unit (DoH)en_US
dc.contributor.icrauthorMoss, Susan Maryen


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