Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie?
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Date
2018-08-14Author
Thompson, MK
Poortmans, P
Chalmers, AJ
Faivre-Finn, C
Hall, E
Huddart, RA
Lievens, Y
Sebag-Montefiore, D
Coles, CE
Type
Journal Article
Metadata
Show full item recordAbstract
As we mark 150 years since the birth of Marie Curie, we reflect on the global advances made in radiation oncology and the current status of radiation therapy (RT) research. Large-scale international RT clinical trials have been fundamental in driving evidence-based change and have served to improve cancer management and to reduce side effects. Radiation therapy trials have also improved practice by increasing quality assurance and consistency in treatment protocols across multiple centres. This review summarises some of the key RT practice-changing clinical trials over the last two decades, in four common cancer sites for which RT is a crucial component of curative treatment: breast, lung, urological and lower gastro-intestinal cancer. We highlight the global inequality in access to RT, and the work of international organisations, such as the International Atomic Energy Agency (IAEA), the European SocieTy for Radiotherapy and Oncology (ESTRO), and the United Kingdom National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad), that aim to improve access to RT and facilitate radiation research. We discuss some emerging RT technologies including proton beam therapy and magnetic resonance linear accelerators and predict likely future directions in clinical RT research.
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Subject
Humans
Neoplasms
Breast Neoplasms
Gastrointestinal Neoplasms
Lung Neoplasms
Urologic Neoplasms
Health Services Accessibility
Europe
Female
Male
Clinical Trials as Topic
Practice Guidelines as Topic
Research team
ICR-CTSU Urology and Head and Neck Trials Team
Clinical Academic Radiotherapy (Huddart)
Language
eng
Date accepted
2018-06-22
License start date
2018-08
Citation
British journal of cancer, 2018, 119 (4), pp. 389 - 407
Publisher
NATURE PUBLISHING GROUP
Except where otherwise noted, this item's license is described
as
https://creativecommons.org/licenses/by/4.0
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