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dc.contributor.authorNovelli, M
dc.contributor.authorCossu, A
dc.contributor.authorOukrif, D
dc.contributor.authorQuaglia, A
dc.contributor.authorLakhani, S
dc.contributor.authorPoulsom, R
dc.contributor.authorSasieni, P
dc.contributor.authorCarta, P
dc.contributor.authorContini, M
dc.contributor.authorPasca, A
dc.contributor.authorPalmieri, G
dc.contributor.authorBodmer, W
dc.contributor.authorTanda, F
dc.contributor.authorWright, N
dc.date.accessioned2018-09-17T08:21:10Z
dc.date.issued2003-03-18
dc.identifier6
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 pp. 3311 - 3314
dc.identifier.issn0027-8424
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2685
dc.identifier.doi10.1073/pnas.0437825100
dc.description.abstractMost models of tumorigenesis assume that tumors are monoclonal in origin. This conclusion is based largely on studies using X chromosome-linked markers in females. One important factor, often ignored in such studies, is the distribution of X-inactivated cells in tissues. Because Iyonization occurs early in development, many of the progeny of a single embryonic stem cell are grouped together in the adult, forming patches. As polyclonality can be demonstrated only at the borders of X-inactivation patches, the patch size is crucial in determining the chance of demonstrating polyclonality and hence the number of tumors that need to be examined to exclude polyclonality. Previously studies using X-linked genes such as glucose-6-phosphate dehydrogenase have been handicapped by the need to destroy the tissues to study the haplotypes of glucose-6-phosphate dehydrogenase [Fialkow, P.A. (1976) Biochim. Biophys. Acta 458, 283-321] or to determine the restriction fragment length polymorphisms of X chromosome-linked genes [Vogelstein, B., Fearon, E. R., Hamilton, S. R. & Feinberg, A. P. (1985) Science 227, 642-645]. Here we visualize X-inactivation patches in human females directly. Results show that the patch size is relatively large in both the human colon and breast, confounding assessment of tumor clonality with traditional X-inactivation studies.
dc.format.extent3311 - 3314
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.titleX-inactivation patch size in human female tissue confounds the assessment of tumor clonality
dc.typeJournal Article
rioxxterms.versionofrecord10.1073/pnas.0437825100
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2003-03-18
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
pubs.notesresearcherid-numbers: Cossu, Antonio/I-8836-2018 Lakhani, Sunil/I-1970-2018 orcid-numbers: Cossu, Antonio/0000-0002-2390-2205 Lakhani, Sunil/0000-0003-4067-2760 Wright, Nicholas/0000-0002-5525-3457 Palmieri, Giuseppe/0000-0002-4350-2276 Bodmer, Walter/0000-0001-6244-9792 Sasieni, Peter/0000-0003-1509-8744 unique-id: ISI:000181675200060
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology
pubs.volume100
pubs.embargo.termsNot known
icr.researchteamMolecular Pathologyen_US
dc.contributor.icrauthorLakhani, Sunilen


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