dc.contributor.author | Piccirillo, SG | |
dc.contributor.author | Spiteri, I | |
dc.contributor.author | Sottoriva, A | |
dc.contributor.author | Touloumis, A | |
dc.contributor.author | Ber, S | |
dc.contributor.author | Price, SJ | |
dc.contributor.author | Heywood, R | |
dc.contributor.author | Francis, N-J | |
dc.contributor.author | Howarth, KD | |
dc.contributor.author | Collins, VP | |
dc.contributor.author | Venkitaraman, AR | |
dc.contributor.author | Curtis, C | |
dc.contributor.author | Marioni, JC | |
dc.contributor.author | Tavaré, S | |
dc.contributor.author | Watts, C | |
dc.date.accessioned | 2018-11-19T12:04:37Z | |
dc.date.issued | 2015-01-01 | |
dc.identifier.citation | Cancer research, 2015, 75 (1), pp. 194 - 202 | |
dc.identifier.issn | 0008-5472 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2941 | |
dc.identifier.eissn | 1538-7445 | |
dc.identifier.doi | 10.1158/0008-5472.can-13-3131 | |
dc.description.abstract | Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance. | |
dc.format | Print-Electronic | |
dc.format.extent | 194 - 202 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER ASSOC CANCER RESEARCH | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | Ependyma | |
dc.subject | Cell Line, Tumor | |
dc.subject | Humans | |
dc.subject | Glioblastoma | |
dc.subject | Brain Neoplasms | |
dc.subject | Drug Resistance, Neoplasm | |
dc.subject | Neoplastic Stem Cells | |
dc.subject | Neural Stem Cells | |
dc.title | Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1158/0008-5472.can-13-3131 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2015-01 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cancer research | |
pubs.issue | 1 | |
pubs.notes | 6 months | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling | |
pubs.publication-status | Published | |
pubs.volume | 75 | |
pubs.embargo.terms | 6 months | |
icr.researchteam | Evolutionary Genomics & Modelling | |
dc.contributor.icrauthor | Spiteri Sagastume, Maria | |
dc.contributor.icrauthor | Sottoriva, Andrea | |