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dc.contributor.authorPiccirillo, SGen_US
dc.contributor.authorSpiteri, Ien_US
dc.contributor.authorSottoriva, Aen_US
dc.contributor.authorTouloumis, Aen_US
dc.contributor.authorBer, Sen_US
dc.contributor.authorPrice, SJen_US
dc.contributor.authorHeywood, Ren_US
dc.contributor.authorFrancis, NJen_US
dc.contributor.authorHowarth, KDen_US
dc.contributor.authorCollins, VPen_US
dc.contributor.authorVenkitaraman, ARen_US
dc.contributor.authorCurtis, Cen_US
dc.contributor.authorMarioni, JCen_US
dc.contributor.authorTavaré, Sen_US
dc.contributor.authorWatts, Cen_US
dc.date.accessioned2018-11-19T12:04:37Z
dc.date.issued2015-01en_US
dc.identifier.citationCancer research, 2015, 75 (1), pp. 194 - 202en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2941
dc.identifier.eissn1538-7445en_US
dc.identifier.doi10.1158/0008-5472.can-13-3131en_US
dc.description.abstractGlioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.en_US
dc.formatPrint-Electronicen_US
dc.format.extent194 - 202en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectEpendymaen_US
dc.subjectCell Line, Tumoren_US
dc.subjectHumansen_US
dc.subjectGlioblastomaen_US
dc.subjectBrain Neoplasmsen_US
dc.subjectDrug Resistance, Neoplasmen_US
dc.subjectNeoplastic Stem Cellsen_US
dc.subjectNeural Stem Cellsen_US
dc.titleContributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1158/0008-5472.can-13-3131en_US
rioxxterms.licenseref.startdate2015-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer researchen_US
pubs.issue1en_US
pubs.notes6 monthsen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling
pubs.volume75en_US
pubs.embargo.terms6 monthsen_US
icr.researchteamEvolutionary Genomics & Modellingen_US
dc.contributor.icrauthorSottoriva, Andreaen_US
dc.contributor.icrauthorSpiteri Sagastume, Mariaen_US


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