Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.
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Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.
Cell Line, Tumor
Drug Resistance, Neoplasm
Neoplastic Stem Cells
Neural Stem Cells
Evolutionary Genomics & Modelling
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Cancer research, 2015, 75 (1), pp. 194 - 202