Now showing items 1-4 of 4

    • DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. 

      Barr, AR; Cooper, S; Heldt, FS; Butera, F; Stoy, H; Mansfeld, J; Novák, B; Bakal, C (2017-03-20)
      Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic ...
    • A Dynamical Framework for the All-or-None G1/S Transition. 

      Barr, AR; Heldt, FS; Zhang, T; Bakal, C; Novák, B (2016-01-27)
      The transition from G1 into DNA replication (S phase) is an emergent behavior resulting from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk inhibitors (CKIs), and the anaphase-promoting ...
    • NucliTrack: an integrated nuclei tracking application. 

      Cooper, S; Barr, AR; Glen, R; Bakal, C (2017-10)
      Live imaging studies give unparalleled insight into dynamic single cell behaviours and fate decisions. However, the challenge of reliably tracking single cells over long periods of time limits both the throughput and ease ...
    • Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer. 

      Asghar, US; Barr, AR; Cutts, R; Beaney, M; Babina, I; Sampath, D; Giltnane, J; Lacap, JA; Crocker, L; Young, A; Pearson, A; Herrera-Abreu, MT; Bakal, C; Turner, NC (2017-09)
      Purpose: Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer that is associated with a poor prognosis. We evaluated the activity of CDK4/6 inhibitors across the TNBC subtypes and investigated ...