Browsing Cancer Biology by author "Isacke, Clare"
Now showing items 1-2 of 2
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Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation.
van Weverwijk, A; Koundouros, N; Iravani, M; Ashenden, M; Gao, Q; et al. (NATURE PUBLISHING GROUP, 2019-06-20)The different stages of the metastatic cascade present distinct metabolic challenges to tumour cells and an altered tumour metabolism associated with successful metastatic colonisation provides a therapeutic vulnerability ... -
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Koundouros, N; Karali, E; Tripp, A; Valle, A; Inglese, P; et al. (CELL PRESS, 2020-06-25)Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown. Using the iKnife ...