Browsing Cancer Biology by author "Pines, Jonathon"
Now showing items 1-3 of 3
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Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy.
Barbiero, M; Cirillo, L; Veerapathiran, S; Coates, C; Ruffilli, C; et al. (ROYAL SOC, 2022-06-29)Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address. This considerable ... -
Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.
Strauss, B; Harrison, A; Coelho, PA; Yata, K; Zernicka-Goetz, M; et al. (ROCKEFELLER UNIV PRESS, 2018-01-02)There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is ... -
Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint.
Jackman, M; Marcozzi, C; Barbiero, M; Pardo, M; Yu, L; et al. (ROCKEFELLER UNIV PRESS, 2020-06-01)How the cell rapidly and completely reorganizes its architecture when it divides is a problem that has fascinated researchers for almost 150 yr. We now know that the core regulatory machinery is highly conserved in eukaryotes, ...