Browsing Cancer Biology by author "Butera, Francesca"
Now showing items 1-3 of 3
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ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.
Rashid, M; van der Horst, M; Mentzel, T; Butera, F; Ferreira, I; et al. (NATURE PUBLISHING GROUP, 2019-05-17)Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation and potential for malignant transformation and aggressive behaviour. We present the genomic analysis of 75 samples from 57 ... -
Characterisation of RELA dynamics in pancreatic ductal adenocarcinoma
Bakal C; Butera, F; Bakal, C (Institute of Cancer Research (University Of London), 2022-07-06)The NF-kB transcription factor RELA is a master regulator of the immune response and cell survival. Numerous studies have determined the parameters and configuration of single cell RELA translocation dynamics, with various ... -
DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.
Barr, AR; Cooper, S; Heldt, FS; Butera, F; Stoy, H; et al. (NATURE PUBLISHING GROUP, 2017-03-20)Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic ...