Browsing Cancer Biology by author "Beuron, Fabienne"
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Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase.
Coster, G; Frigola, J; Beuron, F; Morris, EP; Diffley, JFX (CELL PRESS, 2014-09-04)Loading of the six related Minichromosome Maintenance (MCM) proteins as head-to-head double hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DNA replication in eukaryotic cells. ... -
Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling.
Koliopoulos, MG; Muhammad, R; Roumeliotis, TI; Beuron, F; Choudhary, JS; et al. (NATURE PORTFOLIO, 2022-08-29)Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of protein complexes in a cell cycle-specific manner. Complexes of MuvB with the transcription factors B-MYB and FOXM1 activate ...