Browsing Cancer Biology by author "Cooley, Rachel"
Now showing items 1-3 of 3
-
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110 alpha
Ismail, M; Martin, SR; George, R; Houghton, F; Kelly, G; et al. (NATURE PORTFOLIO, 2023-02-02)<jats:title>Abstract</jats:title><jats:p>P110α is a member of the phosphoinositide 3-kinase (PI3K) enzyme family that functions downstream of RAS. RAS proteins contribute to the activation of p110α by interacting directly ... -
Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets
Cooley, R; Kara, N; Hui, NS; Tart, J; Roustan, C; et al. (F1000 Research Ltd, 2020-01-01)Targeting the interaction of proteins with weak binding affinities or low solubility represents a particular challenge for drug screening. The NanoLuc ® Binary Technology (NanoBiT ®) was originally developed to detect ... -
Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets.
Cooley, R; Kara, N; Hui, NS; Tart, J; Roustan, C; et al. (F1000 Research Ltd, 2020-01-01)Targeting the interaction of proteins with weak binding affinities or low solubility represents a particular challenge for drug screening. The NanoLuc â ® Binary Technology (NanoBiT â ®) was originally developed to detect ...