Browsing Cancer Biology by author "Koundouros, Nikolaos"
Now showing items 1-6 of 6
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Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation.
van Weverwijk, A; Koundouros, N; Iravani, M; Ashenden, M; Gao, Q; et al. (NATURE PUBLISHING GROUP, 2019-06-20)The different stages of the metastatic cascade present distinct metabolic challenges to tumour cells and an altered tumour metabolism associated with successful metastatic colonisation provides a therapeutic vulnerability ... -
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Koundouros, N; Karali, E; Tripp, A; Valle, A; Inglese, P; et al. (CELL PRESS, 2020-06-25)Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown. Using the iKnife ... -
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
Gupta, A; Anjomani-Virmouni, S; Koundouros, N; Dimitriadi, M; Choo-Wing, R; et al. (CELL PRESS, 2017-03-16)PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all ... -
PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN.
Gupta, A; Anjomani-Virmouni, S; Koundouros, N; Poulogiannis, G (TAYLOR & FRANCIS INC, 2017-01-01)Cancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss ... -
Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer.
Koundouros, N; Poulogiannis, G (FRONTIERS MEDIA SA, 2018-05-15)Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant regulation of oncogenic signaling cascades ... -
Reprogramming of fatty acid metabolism in cancer.
Koundouros, N; Poulogiannis, G (SPRINGERNATURE, 2020-01-07)A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. In particular, the importance of altered fatty ...