Now showing items 1-20 of 349

    • Accelerating Live Single-Cell Signalling Studies. 

      Cooper, S; Bakal, C (2017-05)
      The dynamics of signalling networks that couple environmental conditions with cellular behaviour can now be characterised in exquisite detail using live single-cell imaging experiments. Recent improvements in our abilities ...
    • Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development. 

      Gialitakis, M; Tolaini, M; Li, Y; Pardo, M; Yu, L; Toribio, A; Choudhary, JS; Niakan, K; Papayannopoulos, V; Stockinger, B (2017-11)
      The transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. ...
    • Adenoviral strategies for the gene therapy of cancer. 

      Relph, KL; Harrington, KJ; Pandha, H (2005-12)
      Despite slow clinical progress, efforts to develop specific nontoxic cancer gene therapies are increasing exponentially. Adenoviral vectors are one of the most popular vehicles for gene transfer currently being used in ...
    • The Adequacy of Core Biopsy in the Assessment of Smooth Muscle Neoplasms of Soft Tissues: Implications for Treatment and Prognosis. 

      Schneider, N; Strauss, DC; Smith, MJ; Miah, AB; Zaidi, S; Benson, C; van Houdt, WJ; Jones, RL; Hayes, AJ; Fisher, C; Thway, K (2017-07)
      The grading of soft tissue sarcomas is one of the most important prognostic factors and determines patient management. Although grading of most adult-type soft tissue sarcomas on biopsies correlates highly with the final ...
    • The adequacy of tissue microarrays in the assessment of inter- and intra-tumoural heterogeneity of infiltrating lymphocyte burden in leiomyosarcoma. 

      Lee, ATJ; Chew, W; Wilding, CP; Guljar, N; Smith, MJ; Strauss, DC; Fisher, C; Hayes, AJ; Judson, I; Thway, K; Jones, RL; Huang, PH (2019-10-10)
      The characterisation and clinical relevance of tumour-infiltrating lymphocytes (TILs) in leiomyosarcoma (LMS), a subtype of soft tissue sarcoma that exhibits histological heterogeneity, is not established. The use of tissue ...
    • Adult soft tissue myoepithelial carcinoma: treatment outcomes and efficacy of chemotherapy. 

      Chamberlain, F; Cojocaru, E; Scaranti, M; Noujaim, J; Constantinou, A; Thway, K; Fisher, C; Messiou, C; Strauss, DC; Miah, A; Zaidi, S; Benson, C; Gennatas, S; Jones, RL (2019-12-27)
      Soft tissue myoepithelial carcinomas are a rare, malignant subgroup of myoepithelial tumours mostly arising in the extremities with equal predilection for women and men. The mainstay of management of localised disease is ...
    • Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. 

      Neeb, A; Herranz, N; Arce-Gallego, S; Miranda, S; Buroni, L; Yuan, W; Athie, A; Casals, T; Carmichael, J; Rodrigues, DN; Gurel, B; Rescigno, P; Rekowski, J; Welti, J; Riisnaes, R; Gil, V; Ning, J; Wagner, V; Casanova-Salas, I; Cordoba, S; Castro, N; Fenor de la Maza, MD; Seed, G; Chandran, K; Ferreira, A; Figueiredo, I; Bertan, C; Bianchini, D; Aversa, C; Paschalis, A; Gonzalez, M; Morales-Barrera, R; Suarez, C; Carles, J; Swain, A; Sharp, A; Gil, J; Serra, V; Lord, C; Carreira, S; Mateo, J; de Bono, JS (2020-11-08)
      <h4>Background</h4>Deleterious ATM alterations are found in metastatic prostate cancer (PC); PARP inhibition has antitumour activity against this subset, but only some ATM loss PCs respond.<h4>Objective</h4>To characterise ...
    • Advances in mass spectrometry based strategies to study receptor tyrosine kinases. 

      Vyse, S; Desmond, H; Huang, PH (2017-03)
      Receptor tyrosine kinases (RTKs) are key transmembrane environmental sensors that are capable of transmitting extracellular information into phenotypic responses, including cell proliferation, survival and metabolism. ...
    • Afatinib vs Placebo as Adjuvant Therapy After Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial. 

      Burtness, B; Haddad, R; Dinis, J; Trigo, J; Yokota, T; de Souza Viana, L; Romanov, I; Vermorken, J; Bourhis, J; Tahara, M; Martins Segalla, JG; Psyrri, A; Vasilevskaya, I; Nangia, CS; Chaves-Conde, M; Kiyota, N; Homma, A; Holeckova, P; Del Campo, JM; Asarawala, N; Nicolau, UR; Rauch, D; Even, C; Wang, B; Gibson, N; Ehrnrooth, E; Harrington, K; Cohen, EEW; LUX-Head & Neck 2 investigators (2019-06-13)
      <h4>Importance</h4>Locoregionally advanced head and neck squamous cell cancer (HNSCC) is treated curatively; however, risk of recurrence remains high among some patients. The ERBB family blocker afatinib has shown efficacy ...
    • Affibody-Based PET Imaging to Guide EGFR-Targeted Cancer Therapy in Head and Neck Squamous Cell Cancer Models. 

      Burley, TA; Da Pieve, C; Martins, CD; Ciobota, DM; Allott, L; Oyen, WJG; Harrington, KJ; Smith, G; Kramer-Marek, G (2019-03)
      In head and neck squamous cell cancer, the human epidermal growth factor receptor 1 (EGFR) is the dominant signaling molecule among all members of the family. So far, cetuximab is the only approved anti-EGFR monoclonal ...
    • AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts. 

      Sanchez-Alvarez, M; Del Pozo, MA; Bakal, C (2017-11-28)
      Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation ...
    • ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma. 

      Rashid, M; van der Horst, M; Mentzel, T; Butera, F; Ferreira, I; Pance, A; Rütten, A; Luzar, B; Marusic, Z; de Saint Aubain, N; Ko, JS; Billings, SD; Chen, S; Abi Daoud, M; Hewinson, J; Louzada, S; Harms, PW; Cerretelli, G; Robles-Espinoza, CD; Patel, RM; van der Weyden, L; Bakal, C; Hornick, JL; Arends, MJ; Brenn, T; Adams, DJ (2019-05-17)
      Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation and potential for malignant transformation and aggressive behaviour. We present the genomic analysis of 75 samples from 57 ...
    • Alterations in the phosphoproteomic profile of cells expressing a non-functional form of the SHP2 phosphatase. 

      Corallino, S; Iwai, LK; Payne, LS; Huang, PH; Sacco, F; Cesareni, G; Castagnoli, L (2016-09)
      The phosphatase SHP-2 plays an essential role in growth factor signaling and mutations in its locus is the cause of congenital and acquired pathologies. Mutations of SHP-2 are known to affect the activation of the RAS ...
    • Analysis of R-Ras signalling pathways 

      Paterson, H (2001-04)
      Analysis of R-Ras signalling pathways. R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and ill- Ras. Activated versions of Ras and TC21 are highly transforming ...
    • Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer. 

      Fletcher, CE; Sulpice, E; Combe, S; Shibakawa, A; Leach, DA; Hamilton, MP; Chrysostomou, SL; Sharp, A; Welti, J; Yuan, W; Dart, DA; Knight, E; Ning, J; Francis, JC; Kounatidou, EE; Gaughan, L; Swain, A; Lupold, SE; de Bono, JS; McGuire, SE; Gidrol, X; Bevan, CL (2019-07)
      Androgen receptor (AR) signalling is a key prostate cancer (PC) driver, even in advanced 'castrate-resistant' disease (CRPC). To systematically identify microRNAs (miRs) modulating AR activity in lethal disease, ...
    • APOBEC and cancer viroimmunotherapy: Thinking the Unthinkable. 

      Vile, RG; Melcher, A; Pandha, H; Harrington, KJ; Pulido, JS (2021-02-08)
      The apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) family protects against infection by degrading incoming viral genomes through cytosine deamination. Here, we review how the potential to unleash these ...
    • APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy. 

      Driscoll, CB; Schuelke, MR; Kottke, T; Thompson, JM; Wongthida, P; Tonne, JM; Huff, AL; Miller, A; Shim, KG; Molan, A; Wetmore, C; Selby, P; Samson, A; Harrington, K; Pandha, H; Melcher, A; Pulido, JS; Harris, R; Evgin, L; Vile, RG (2020-02-07)
      APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity also drives generation of neoepitopes, which ...
    • Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma. 

      Girotti, MR; Gremel, G; Lee, R; Galvani, E; Rothwell, D; Viros, A; Mandal, AK; Lim, KHJ; Saturno, G; Furney, SJ; Baenke, F; Pedersen, M; Rogan, J; Swan, J; Smith, M; Fusi, A; Oudit, D; Dhomen, N; Brady, G; Lorigan, P; Dive, C; Marais, R (2016-03)
      <h4>Unlabelled</h4>Targeted therapies and immunotherapies have transformed melanoma care, extending median survival from ∼9 to over 25 months, but nevertheless most patients still die of their disease. The aim of precision ...
    • ART DECO (CRUK/10/018): dose escalated vs standard dose IMRT in locally advanced head and neck cancer 

      Nutting, C; Morden, J; Bernstein, D; Beasley, M; Cosgrove, V; Fisher, S; Foran, B; Guerrero-Urbano, T; Gujral, D; Harrington, K; Junor, E; Mehanna, H; Miah, A; Palaniappan, N; Ramkumar, S; Sanghera, P; Sen, M; Sibtain, A; Soe, W; West, C; Piercey, D; Witts, S; Emson, M; Hall, E (ELSEVIER IRELAND LTD, 2017-03-01)
    • Asparagine bioavailability governs metastasis in a model of breast cancer. 

      Knott, SRV; Wagenblast, E; Khan, S; Kim, SY; Soto, M; Wagner, M; Turgeon, M-O; Fish, L; Erard, N; Gable, AL; Maceli, AR; Dickopf, S; Papachristou, EK; D'Santos, CS; Carey, LA; Wilkinson, JE; Harrell, JC; Perou, CM; Goodarzi, H; Poulogiannis, G; Hannon, GJ (2018-02-07)
      Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary ...