Now showing items 1-20 of 369

    • A caveolin-dependent and PI3K/AKT-independent role of PTEN in beta-catenin transcriptional activity 

      Pendersen, Malin; Pedersen, Malin (2015-08)
      Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss ...
    • A commercial antibody to the human condensin II subunit NCAPH2 cross-reacts with a SWI/SNF complex component 

      Cutts, E; Taylor, G; Pardo, M; Yu, L; Wills, J; Choudhary, J; Vannini, A; Wood, A (2021-01-13)
      Condensin complexes compact and disentangle chromosomes in preparation for cell division. Commercially available antibodies raised against condensin subunits have been widely used to characterise their cellular interactome. ...
    • A commercial antibody to the human condensin II subunit NCAPH2 cross-reacts with a SWI/SNF complex component. 

      Cutts, EE; Taylor, GC; Pardo, M; Yu, L; Wills, JC; Choudhary, JS; Vannini, A; Wood, AJ (2021-01-13)
      Condensin complexes compact and disentangle chromosomes in preparation for cell division. Commercially available antibodies raised against condensin subunits have been widely used to characterise their cellular interactome. ...
    • A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells. 

      Heldt, FS; Barr, AR; Cooper, S; Bakal, C; Novák, B (2018-03)
      Human cells that suffer mild DNA damage can enter a reversible state of growth arrest known as quiescence. This decision to temporarily exit the cell cycle is essential to prevent the propagation of mutations, and most ...
    • A Dynamical Framework for the All-or-None G1/S Transition. 

      Barr, AR; Heldt, FS; Zhang, T; Bakal, C; Novák, B (2016-01-27)
      The transition from G1 into DNA replication (S phase) is an emergent behavior resulting from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk inhibitors (CKIs), and the anaphase-promoting ...
    • A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. 

      Stojic, L; Lun, ATL; Mascalchi, P; Ernst, C; Redmond, AM; Mangei, J; Barr, AR; Bousgouni, V; Bakal, C; Marioni, JC; Odom, DT; Gergely, F (2020-04-15)
      Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more ...
    • A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts. 

      Krasny, L; Bland, P; Burns, J; Lima, NC; Harrison, PT; Pacini, L; Elms, ML; Ning, J; Martinez, VG; Yu, Y-R; Acton, SE; Ho, P-C; Calvo, F; Swain, A; Howard, BA; Natrajan, RC; Huang, PH (2020-07-14)
      SWATH-mass spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here, we present a comprehensive mouse reference spectral library (MouseRefSWATH) that ...
    • A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma. 

      Box, C; Mendiola, M; Gowan, S; Box, GM; Valenti, M; Brandon, ADH; Al-Lazikani, B; Rogers, SJ; Wilkins, A; Harrington, KJ; Eccles, SA (2013-07)
      Background Acquired resistance to tyrosine kinase inhibitors (TKIs) is becoming a major challenge in the treatment of many cancers. Epidermal growth factor receptor (EGFR) is overexpressed in squamous carcinomas, notably ...
    • A practical guide to the handling and administration of talimogene laherparepvec in Europe. 

      Harrington, KJ; Michielin, O; Malvehy, J; Pezzani Grüter, I; Grove, L; Frauchiger, AL; Dummer, R (2017-01)
      Talimogene laherparepvec is a herpes simplex virus-1-based intralesional oncolytic immunotherapy and is the first oncolytic virus to be approved in Europe. It is indicated for the treatment of adults with unresectable ...
    • A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer. 

      Wong, KH; Kuciejewska, A; Sharabiani, MTA; Ng-Cheng-Hin, B; Hoy, S; Hurley, T; Rydon, J; Grove, L; Santos, A; Ryugenji, M; Bhide, SA; Nutting, CM; Harrington, KJ; Newbold, KL (2017-02)
      Purpose This phase III, non-blinded, parallel-group, randomised controlled study evaluated the efficacy of Caphosol mouthwash in the management of radiation-induced oral mucositis (OM) in patients with head and neck cancer ...
    • Accelerating Live Single-Cell Signalling Studies. 

      Cooper, S; Bakal, C (2017-05)
      The dynamics of signalling networks that couple environmental conditions with cellular behaviour can now be characterised in exquisite detail using live single-cell imaging experiments. Recent improvements in our abilities ...
    • Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development. 

      Gialitakis, M; Tolaini, M; Li, Y; Pardo, M; Yu, L; Toribio, A; Choudhary, JS; Niakan, K; Papayannopoulos, V; Stockinger, B (2017-11)
      The transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. ...
    • Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study 

      Fendler, A; Shepherd, STC; Au, L; Wilkinson, KA; Wu, M; Byrne, F; Cerrone, M; Schmitt, AM; Joharatnam-Hogan, N; Shum, B; Tippu, Z; Rzeniewicz, K; Boos, LA; Harvey, R; Carlyle, E; Edmonds, K; Del Rosario, L; Sarker, S; Lingard, K; Mangwende, M; Holt, L; Ahmod, H; Korteweg, J; Foley, T; Bazin, J; Gordon, W; Barber, T; Emslie-Henry, A; Xie, W; Gerard, CL; Deng, D; Wall, EC; Agua-Doce, A; Namjou, S; Caidan, S; Gavrielides, M; MacRae, J; Kelly, G; Peat, K; Kelly, D; Murra, A; Kelly, K; O'Flaherty, M; Dowdie, L; Ash, N; Gronthoud, F; Shea, RL; Gardner, G; Murray, D; Kinnaird, F; Cui, W; Pascual, J; Rodney, S; Mencel, J; Curtis, O; Stephenson, C; Robinson, A; Oza, B; Farag, S; Leslie, I; Rogiers, A; Iyengar, S; Ethell, M; Messiou, C; Cunningham, D; Chau, I; Starling, N; Turner, N; Welsh, L; van As, N; Jones, RL; Droney, J; Banerjee, S; Tatham, KC; O'Brien, M; Harrington, K; Bhide, S; Okines, A; Reid, A; Young, K; Furness, AJS; Pickering, L; Swanton, C; Gandhi, S; Gamblin, S; Bauer, DL; Kassiotis, G; Kumar, S; Yousaf, N; Jhanji, S; Nicholson, E; Howell, M; Walker, S; Wilkinson, RJ; Larkin, J; Turajlic, S (NATURE PORTFOLIO, 2021-10-27)
    • Adenoviral strategies for the gene therapy of cancer. 

      Relph, KL; Harrington, KJ; Pandha, H (2005-12)
      Despite slow clinical progress, efforts to develop specific nontoxic cancer gene therapies are increasing exponentially. Adenoviral vectors are one of the most popular vehicles for gene transfer currently being used in ...
    • Adult soft tissue myoepithelial carcinoma: treatment outcomes and efficacy of chemotherapy. 

      Chamberlain, F; Cojocaru, E; Scaranti, M; Noujaim, J; Constantinou, A; Thway, K; Fisher, C; Messiou, C; Strauss, DC; Miah, A; Zaidi, S; Benson, C; Gennatas, S; Jones, RL (2019-12-27)
      Soft tissue myoepithelial carcinomas are a rare, malignant subgroup of myoepithelial tumours mostly arising in the extremities with equal predilection for women and men. The mainstay of management of localised disease is ...
    • Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. 

      Neeb, A; Herranz, N; Arce-Gallego, S; Miranda, S; Buroni, L; Yuan, W; Athie, A; Casals, T; Carmichael, J; Rodrigues, DN; Gurel, B; Rescigno, P; Rekowski, J; Welti, J; Riisnaes, R; Gil, V; Ning, J; Wagner, V; Casanova-Salas, I; Cordoba, S; Castro, N; Fenor de la Maza, MD; Seed, G; Chandran, K; Ferreira, A; Figueiredo, I; Bertan, C; Bianchini, D; Aversa, C; Paschalis, A; Gonzalez, M; Morales-Barrera, R; Suarez, C; Carles, J; Swain, A; Sharp, A; Gil, J; Serra, V; Lord, C; Carreira, S; Mateo, J; de Bono, JS (2020-11-08)
      Background Deleterious ATM alterations are found in metastatic prostate cancer (PC); PARP inhibition has antitumour activity against this subset, but only some ATM loss PCs respond.Objective To characterise ATM-deficient ...
    • Advances in mass spectrometry based strategies to study receptor tyrosine kinases. 

      Vyse, S; Desmond, H; Huang, PH (2017-03)
      Receptor tyrosine kinases (RTKs) are key transmembrane environmental sensors that are capable of transmitting extracellular information into phenotypic responses, including cell proliferation, survival and metabolism. ...
    • Afatinib vs Placebo as Adjuvant Therapy After Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial. 

      Burtness, B; Haddad, R; Dinis, J; Trigo, J; Yokota, T; de Souza Viana, L; Romanov, I; Vermorken, J; Bourhis, J; Tahara, M; Martins Segalla, JG; Psyrri, A; Vasilevskaya, I; Nangia, CS; Chaves-Conde, M; Kiyota, N; Homma, A; Holeckova, P; Del Campo, JM; Asarawala, N; Nicolau, UR; Rauch, D; Even, C; Wang, B; Gibson, N; Ehrnrooth, E; Harrington, K; Cohen, EEW; LUX-Head & Neck 2 investigators (2019-06-13)
      Importance Locoregionally advanced head and neck squamous cell cancer (HNSCC) is treated curatively; however, risk of recurrence remains high among some patients. The ERBB family blocker afatinib has shown efficacy in ...
    • Affibody-Based PET Imaging to Guide EGFR-Targeted Cancer Therapy in Head and Neck Squamous Cell Cancer Models. 

      Burley, TA; Da Pieve, C; Martins, CD; Ciobota, DM; Allott, L; Oyen, WJG; Harrington, KJ; Smith, G; Kramer-Marek, G (2019-03)
      In head and neck squamous cell cancer, the human epidermal growth factor receptor 1 (EGFR) is the dominant signaling molecule among all members of the family. So far, cetuximab is the only approved anti-EGFR monoclonal ...
    • AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts. 

      Sanchez-Alvarez, M; Del Pozo, MA; Bakal, C (2017-11-28)
      Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation ...