Search
Now showing items 1-3 of 3
The response of the Eukaryotic replisome to DNA quadruplex structures
(Institute of Cancer Research (University Of London), 2024-01-18)
Sequences that can form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play a range of physiological roles. However, they can pose a challenge to ...
Replication-induced DNA secondary structures drive fork uncoupling and breakage.
(WILEY, 2023-11-15)
Sequences that form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play various physiological roles. However, they can also interfere with replication ...
The mechanism of replication stalling and recovery within repetitive DNA.
(NATURE PORTFOLIO, 2022-07-19)
Accurate chromosomal DNA replication is essential to maintain genomic stability. Genetic evidence suggests that certain repetitive sequences impair replication, yet the underlying mechanism is poorly defined. Replication ...