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Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
(CELL PRESS, 2018-06-05)
Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer ...
Dietary omega 6/3 fats and aspirin govern PI3Ka-induced oncogenicity
Oncogenic mutations in PI3KCA, the gene encoding the p110a catalytic subunit of PI3K, represent one of the most frequent genetic alterations in human cancer. Although multiple inhibitors of the PI3K/AKT/mTOR pathway have ...