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Investigating roles of the SWI/SNF complex subunits in genome stability, chromatin organisation, innate immune signalling and replication stress
(Institute of Cancer Research (University Of London), 2021-12-31)
The alterations of the SWI/SNF chromatin remodelling complex subunits happen in 30% of malignancies. The exact mechanisms by which SWI/SNF alterations contribute to tumourigenesis are still not entirely clear. Here, I ...
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.
(NATURE RESEARCH, 2020-11-13)
Chromatin structure is dynamically reorganized at multiple levels in response to DNA double-strand breaks (DSBs). Yet, how the different steps of chromatin reorganization are coordinated in space and time to differentially ...
WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming.
(CELL PRESS, 2019-04-09)
Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by expression of the OSKM transcription factors. Despite significant effort, relatively little is known about the cellular requirements ...
Chromatin modifiers and remodellers in DNA repair and signalling.
(ROYAL SOC, 2017-10-05)
Perspectives on ENCODE.
(NATURE RESEARCH, 2020-07-30)
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated ...
Removal of H2A.Z by INO80 promotes homologous recombination.
(WILEY, 2015-08-01)
The mammalian INO80 remodelling complex facilitates homologous recombination (HR), but the mechanism by which it does this is unclear. Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with ...
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.
(NATURE PUBLISHING GROUP, 2018-06-01)
The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a ...
Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress.
(NATURE PORTFOLIO, 2023-01-20)
The transcriptional response to genotoxic stress involves gene expression arrest, followed by recovery of mRNA synthesis (RRS) after DNA repair. We find that the lack of the EXD2 nuclease impairs RRS and decreases cell ...