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Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers.
(2021-03-19)
Advanced non-small-cell lung cancer (NSCLC) patients with EGFR T790M-positive tumours benefit from osimertinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Here we show that the size of the ...
WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.
(2020-11-21)
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer that lacks the oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, making it difficult to target ...
Investigating roles of the SWI/SNF complex subunits in genome stability, chromatin organisation, innate immune signalling and replication stress
(Institute of Cancer Research (University Of London), 2021-12-31)
The alterations of the SWI/SNF chromatin remodelling complex subunits happen in 30% of malignancies. The exact mechanisms by which SWI/SNF alterations contribute to tumourigenesis are still not entirely clear. Here, I ...
How RhoGEFs drive triple negative breast cancer cell invasion through the activation of YAP and TAZ
(Institute of Cancer Research (University Of London), 2020-03-31)
Dynamical remodelling of the cytoskeleton is essential for triple negative breast cancer metastasis (TNBC). Cell shape is regulated by RhoGEFs which activate Rho GTPases resulting in changes in actin polymerisation, ...
Investigating the role of DTX3L in the replication stress response
(Institute of Cancer Research (University Of London), 2023-01-20)
DNA replication must be carried out with high fidelity to ensure accurate transfer of genetic information upon cell division. The mechanisms by which damage upon DNA is repaired are extensive and are increasingly well ...
Pembrolizumab alone or with chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: Health-related quality-of-life results from KEYNOTE-048.
(ELSEVIER, 2022-05-01)
OBJECTIVES: To assess health-related quality of life (HRQoL) with first-line pembrolizumab, pembrolizumab-chemotherapy, or cetuximab-chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) ...
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition.
(NATURE PORTFOLIO, 2022-02-17)
The development of covalent inhibitors against KRAS G12C represents a major milestone in treatment of RAS-driven cancers, especially in non-small cell lung cancer (NSCLC), where KRAS G12C is one of the most common oncogenic ...
Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy.
(ROYAL SOC, 2022-06-29)
Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address. This considerable ...
Identification of phenotype-specific networks from paired gene expression-cell shape imaging data.
(COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2022-04-01)
The morphology of breast cancer cells is often used as an indicator of tumor severity and prognosis. Additionally, morphology can be used to identify more fine-grained, molecular developments within a cancer cell, such as ...