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Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.
(NATURE PORTFOLIO, 2023-05-03)
Lysine acetylation in histone tails is a key post-translational modification that controls transcription activation. Histone deacetylase complexes remove histone acetylation, thereby repressing transcription and regulating ...
Regulators of male and female sexual development are critical for the transmission of a malaria parasite.
(CELL PRESS, 2023-02-08)
Malaria transmission to mosquitoes requires a developmental switch in asexually dividing blood-stage parasites to sexual reproduction. In Plasmodium berghei, the transcription factor AP2-G is required and sufficient for ...
The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models.
(CELL PRESS, 2023-03-30)
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of 1,635 ...
Characterization of proteome-size scaling by integrative omics reveals mechanisms of proliferation control in cancer.
(AMER ASSOC ADVANCEMENT SCIENCE, 2023-01-25)
Almost all living cells maintain size uniformity through successive divisions. Proteins that over and underscale with size can act as rheostats, which regulate cell cycle progression. Using a multiomic strategy, we leveraged ...
Identifying and characterising Thrap3, Bclaf1 and Erh interactions using cross-linking mass spectrometry
(F1000 Research Ltd, 2023-01-06)
<ns3:p><ns3:bold>Background: </ns3:bold>Cross-linking mass spectrometry (XL-MS) is a powerful technology capable of yielding structural insights across the complex cellular protein interaction network. However, up to date ...