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Perioperative events influence cancer recurrence risk after surgery.
(NATURE PUBLISHING GROUP, 2018-04-01)
Surgery is a mainstay treatment for patients with solid tumours. However, despite surgical resection with a curative intent and numerous advances in the effectiveness of (neo)adjuvant therapies, metastatic disease remains ...
Asparagine bioavailability governs metastasis in a model of breast cancer.
(NATURE PORTFOLIO, 2018-02-15)
Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary ...
DNA Damage, Repair, and Cancer Metabolism.
(FRONTIERS MEDIA SA, 2018-02-05)
Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored. In this review, we examine ...
Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer.
(FRONTIERS MEDIA SA, 2018-05-15)
Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant regulation of oncogenic signaling cascades ...