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A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells.
(NATL ACAD SCIENCES, 2018-03-06)
Human cells that suffer mild DNA damage can enter a reversible state of growth arrest known as quiescence. This decision to temporarily exit the cell cycle is essential to prevent the propagation of mutations, and most ...
Mechanical and Systems Biology of Cancer.
(ELSEVIER SCIENCE BV, 2018-01-01)
Mechanics and biochemical signaling are both often deregulated in cancer, leading toincreased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical ...