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dc.contributor.authorWu, Len_US
dc.contributor.authorShi, Wen_US
dc.contributor.authorLong, Jen_US
dc.contributor.authorGuo, Xen_US
dc.contributor.authorMichailidou, Ken_US
dc.contributor.authorBeesley, Jen_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorShu, X-Oen_US
dc.contributor.authorLu, Yen_US
dc.contributor.authorCai, Qen_US
dc.contributor.authorAl-Ejeh, Fen_US
dc.contributor.authorRozali, Een_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorLi, Ben_US
dc.contributor.authorZeng, Cen_US
dc.contributor.authorFeng, Hen_US
dc.contributor.authorGusev, Aen_US
dc.contributor.authorBarfield, RTen_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorAronson, KJen_US
dc.contributor.authorAuer, PLen_US
dc.contributor.authorBarrdahl, Men_US
dc.contributor.authorBaynes, Cen_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBermisheva, Men_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorBogdanova, NVen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorBrinton, Len_US
dc.contributor.authorBroberg, Pen_US
dc.contributor.authorBrucker, SYen_US
dc.contributor.authorBurwinkel, Ben_US
dc.contributor.authorCaldés, Ten_US
dc.contributor.authorCanzian, Fen_US
dc.contributor.authorCarter, BDen_US
dc.contributor.authorCastelao, JEen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorChen, Xen_US
dc.contributor.authorCheng, T-YDen_US
dc.contributor.authorChristiansen, Hen_US
dc.contributor.authorClarke, CLen_US
dc.contributor.authorNBCS Collaboratorsen_US
dc.contributor.authorCollée, Men_US
dc.contributor.authorCornelissen, Sen_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorCox, Den_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorCunningham, JMen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorDaly, MBen_US
dc.contributor.authorDevilee, Pen_US
dc.contributor.authorDoheny, KFen_US
dc.contributor.authorDörk, Ten_US
dc.contributor.authorDos-Santos-Silva, Ien_US
dc.contributor.authorDumont, Men_US
dc.contributor.authorDwek, Men_US
dc.contributor.authorEccles, DMen_US
dc.contributor.authorEilber, Uen_US
dc.contributor.authorEliassen, AHen_US
dc.contributor.authorEngel, Cen_US
dc.contributor.authorEriksson, Men_US
dc.contributor.authorFachal, Len_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorFlesch-Janys, Den_US
dc.contributor.authorFletcher, Oen_US
dc.contributor.authorFlyger, Hen_US
dc.contributor.authorFritschi, Len_US
dc.contributor.authorGabrielson, Men_US
dc.contributor.authorGago-Dominguez, Men_US
dc.contributor.authorGapstur, SMen_US
dc.contributor.authorGarcía-Closas, Men_US
dc.contributor.authorGaudet, MMen_US
dc.contributor.authorGhoussaini, Men_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGoldberg, MSen_US
dc.contributor.authorGoldgar, DEen_US
dc.contributor.authorGonzález-Neira, Aen_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorHahnen, Een_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorHåkansson, Nen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorHallberg, Een_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorHarrington, Pen_US
dc.contributor.authorHein, Aen_US
dc.contributor.authorHicks, Ben_US
dc.contributor.authorHillemanns, Pen_US
dc.contributor.authorHollestelle, Aen_US
dc.contributor.authorHoover, RNen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorHuang, Gen_US
dc.contributor.authorHumphreys, Ken_US
dc.contributor.authorHunter, DJen_US
dc.contributor.authorJakubowska, Aen_US
dc.contributor.authorJanni, Wen_US
dc.contributor.authorJohn, EMen_US
dc.contributor.authorJohnson, Nen_US
dc.contributor.authorJones, Ken_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorJung, Aen_US
dc.contributor.authorKaaks, Ren_US
dc.contributor.authorKerin, MJen_US
dc.contributor.authorKhusnutdinova, Een_US
dc.contributor.authorKosma, V-Men_US
dc.contributor.authorKristensen, VNen_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorLindström, Sen_US
dc.contributor.authorLissowska, Jen_US
dc.contributor.authorLo, W-Yen_US
dc.contributor.authorLoibl, Sen_US
dc.contributor.authorLubinski, Jen_US
dc.contributor.authorLuccarini, Cen_US
dc.contributor.authorLux, MPen_US
dc.contributor.authorMacInnis, RJen_US
dc.contributor.authorMaishman, Ten_US
dc.contributor.authorKostovska, IMen_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorManson, JEen_US
dc.contributor.authorMargolin, Sen_US
dc.contributor.authorMavroudis, Den_US
dc.contributor.authorMeijers-Heijboer, Hen_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorMenon, Uen_US
dc.contributor.authorMeyer, Jen_US
dc.contributor.authorMulligan, AMen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorNeven, Pen_US
dc.contributor.authorNielsen, SFen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorOlopade, OIen_US
dc.contributor.authorOlson, JEen_US
dc.contributor.authorOlsson, Hen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authorPlaseska-Karanfilska, Den_US
dc.contributor.authorPrentice, Ren_US
dc.contributor.authorPresneau, Nen_US
dc.contributor.authorPylkäs, Ken_US
dc.contributor.authorRack, Ben_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorRahman, Nen_US
dc.contributor.authorRennert, Gen_US
dc.contributor.authorRennert, HSen_US
dc.contributor.authorRhenius, Ven_US
dc.contributor.authorRomero, Aen_US
dc.contributor.authorRomm, Jen_US
dc.contributor.authorRudolph, Aen_US
dc.contributor.authorSaloustros, Een_US
dc.contributor.authorSandler, DPen_US
dc.contributor.authorSawyer, EJen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorSchneeweiss, Aen_US
dc.contributor.authorScott, RJen_US
dc.contributor.authorScott, CGen_US
dc.contributor.authorSeal, Sen_US
dc.contributor.authorShah, Men_US
dc.contributor.authorShrubsole, MJen_US
dc.contributor.authorSmeets, Aen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorSpinelli, JJen_US
dc.contributor.authorStone, Jen_US
dc.contributor.authorSurowy, Hen_US
dc.contributor.authorSwerdlow, AJen_US
dc.contributor.authorTamimi, RMen_US
dc.contributor.authorTapper, Wen_US
dc.contributor.authorTaylor, JAen_US
dc.contributor.authorTerry, MBen_US
dc.contributor.authorTessier, DCen_US
dc.contributor.authorThomas, Aen_US
dc.contributor.authorThöne, Ken_US
dc.contributor.authorTollenaar, RAEMen_US
dc.contributor.authorTorres, Den_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorUntch, Men_US
dc.contributor.authorVachon, Cen_US
dc.contributor.authorVan Den Berg, Den_US
dc.contributor.authorVincent, Den_US
dc.contributor.authorWaisfisz, Qen_US
dc.contributor.authorWeinberg, CRen_US
dc.contributor.authorWendt, Cen_US
dc.contributor.authorWhittemore, ASen_US
dc.contributor.authorWildiers, Hen_US
dc.contributor.authorWillett, WCen_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorWolk, Aen_US
dc.contributor.authorXia, Len_US
dc.contributor.authorYang, XRen_US
dc.contributor.authorZiogas, Aen_US
dc.contributor.authorZiv, Een_US
dc.contributor.authorkConFab/AOCS Investigatorsen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorPharoah, PDPen_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorEdwards, SLen_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorZheng, Wen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2019-01-14T09:48:01Z
dc.date.issued2018-07en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29915430en_US
dc.identifier10.1038/s41588-018-0132-xen_US
dc.identifier.citationNat Genet, 2018, 50 (7), pp. 968 - 978en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3001
dc.identifier.eissn1546-1718en_US
dc.identifier.doi10.1038/s41588-018-0132-xen_US
dc.description.abstractThe breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas. Of the 8,597 genes evaluated, significant associations were identified for 48 at a Bonferroni-corrected threshold of P < 5.82 × 10-6, including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.en_US
dc.format.extent968 - 978en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.subjectBreast Neoplasmsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectFemaleen_US
dc.subjectGene Expressionen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenome-Wide Association Studyen_US
dc.subjectHumansen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectRisken_US
dc.subjectTranscriptomeen_US
dc.titleA transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-04-17en_US
rioxxterms.versionofrecord10.1038/s41588-018-0132-xen_US
rioxxterms.licenseref.startdate2018-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNat Geneten_US
pubs.issue7en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublisheden_US
pubs.volume50en_US
pubs.embargo.termsNot knownen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorFletcher, Oliviaen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorJones, Michaelen_US


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