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dc.contributor.authorSchmidt, MK
dc.contributor.authorHogervorst, F
dc.contributor.authorvan Hien, R
dc.contributor.authorCornelissen, S
dc.contributor.authorBroeks, A
dc.contributor.authorAdank, MA
dc.contributor.authorMeijers, H
dc.contributor.authorWaisfisz, Q
dc.contributor.authorHollestelle, A
dc.contributor.authorSchutte, M
dc.contributor.authorvan den Ouweland, A
dc.contributor.authorHooning, M
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntonenkova, NN
dc.contributor.authorAntoniou, AC
dc.contributor.authorArndt, V
dc.contributor.authorBermisheva, M
dc.contributor.authorBogdanova, NV
dc.contributor.authorBolla, MK
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrüning, T
dc.contributor.authorBurwinkel, B
dc.contributor.authorChang-Claude, J
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDunning, AM
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFletcher, O
dc.contributor.authorFlyger, H
dc.contributor.authorGalle, E
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGiles, GG
dc.contributor.authorHaeberle, L
dc.contributor.authorHall, P
dc.contributor.authorHillemanns, P
dc.contributor.authorHopper, JL
dc.contributor.authorJakubowska, A
dc.contributor.authorJohn, EM
dc.contributor.authorJones, M
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKnight, JA
dc.contributor.authorKosma, V-M
dc.contributor.authorKristensen, V
dc.contributor.authorLee, A
dc.contributor.authorLindblom, A
dc.contributor.authorLubinski, J
dc.contributor.authorMannermaa, A
dc.contributor.authorMargolin, S
dc.contributor.authorMeindl, A
dc.contributor.authorMilne, RL
dc.contributor.authorMuranen, TA
dc.contributor.authorNewcomb, PA
dc.contributor.authorOffit, K
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorPeto, J
dc.contributor.authorPharoah, PDP
dc.contributor.authorRobson, M
dc.contributor.authorRudolph, A
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSeynaeve, C
dc.contributor.authorSoens, J
dc.contributor.authorSouthey, MC
dc.contributor.authorSpurdle, AB
dc.contributor.authorSurowy, H
dc.contributor.authorSwerdlow, A
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTomlinson, I
dc.contributor.authorTrentham-Dietz, A
dc.contributor.authorVachon, C
dc.contributor.authorWang, Q
dc.contributor.authorWhittemore, AS
dc.contributor.authorZiogas, A
dc.contributor.authorvan der Kolk, L
dc.contributor.authorNevanlinna, H
dc.contributor.authorDörk, T
dc.contributor.authorBojesen, S
dc.contributor.authorEaston, DF
dc.date.accessioned2019-01-17T11:01:58Z
dc.date.issued2016-08
dc.identifier.citationJournal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, 34 (23), pp. 2750 - 2760
dc.identifier.issn0732-183X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3013
dc.identifier.eissn1527-7755
dc.identifier.doi10.1200/jco.2016.66.5844
dc.description.abstractPurpose CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC.Patients and methods CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies.Results Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center-based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10(-20)). The OR was higher for estrogen receptor (ER)-positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10(-21)]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10(-4)). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom.Conclusion These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up.
dc.formatPrint-Electronic
dc.format.extent2750 - 2760
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectReceptors, Estrogen
dc.subjectReceptors, Progesterone
dc.subjectOdds Ratio
dc.subjectRisk Assessment
dc.subjectCase-Control Studies
dc.subjectAge Factors
dc.subjectSequence Deletion
dc.subjectHeterozygote
dc.subjectHomozygote
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectCheckpoint Kinase 2
dc.titleAge- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
dc.typeJournal Article
rioxxterms.versionofrecord10.1200/jco.2016.66.5844
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJournal of clinical oncology : official journal of the American Society of Clinical Oncology
pubs.issue23
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume34
pubs.embargo.termsNot known
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorFletcher, Oliviaen
dc.contributor.icrauthorJones, Michaelen
dc.contributor.icrauthorSwerdlow, Anthonyen


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