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dc.contributor.authorFanelli, GNen_US
dc.contributor.authorGasparini, Pen_US
dc.contributor.authorCoati, Ien_US
dc.contributor.authorCui, Ren_US
dc.contributor.authorPakula, Hen_US
dc.contributor.authorChowdhury, Ben_US
dc.contributor.authorValeri, Nen_US
dc.contributor.authorLoupakis, Fen_US
dc.contributor.authorKupcinskas, Jen_US
dc.contributor.authorCappellesso, Ren_US
dc.contributor.authorFassan, Men_US
dc.coverage.spatialNetherlandsen_US
dc.date.accessioned2019-02-20T08:22:53Z
dc.date.issued2018-12en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30533569en_US
dc.identifierS2468-0540(18)30086-6en_US
dc.identifier.citationNoncoding RNA Res, 2018, 3 (4), pp. 195 - 212en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3075
dc.identifier.eissn2468-0540en_US
dc.identifier.doi10.1016/j.ncrna.2018.10.001en_US
dc.description.abstractDespite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying 'targetable' molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. At least 98% of our genome is actively transcribed into non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding capacity. Many studies have demonstrated that lncRNAs are functional genomic elements playing pivotal roles in main oncogenic processes. LncRNA can act at multiple levels developing a complex molecular network that can modulate directly or indirectly the expression of genes involved in tumorigenesis. In this review, we focus on lncRNAs as emerging players in gastro-esophageal carcinogenesis and critically assess their potential as reliable noninvasive biomarkers and in next generation targeted therapies.en_US
dc.format.extent195 - 212en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBiomarkersen_US
dc.subjectEsophageal canceren_US
dc.subjectGastric canceren_US
dc.subjectLong noncoding RNAsen_US
dc.titleLONG-NONCODING RNAs in gastroesophageal cancers.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-10-26en_US
rioxxterms.versionofrecord10.1016/j.ncrna.2018.10.001en_US
rioxxterms.licenseref.startdate2018-12en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNoncoding RNA Resen_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.publication-statusPublished onlineen_US
pubs.volume3en_US
pubs.embargo.termsNot knownen_US
icr.researchteamGastrointestinal Cancer Biology and Genomicsen_US
dc.contributor.icrauthorValeri, Nicolaen_US


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