dc.contributor.author | Went, M | |
dc.contributor.author | Sud, A | |
dc.contributor.author | Li, N | |
dc.contributor.author | Johnson, DC | |
dc.contributor.author | Mitchell, JS | |
dc.contributor.author | Kaiser, M | |
dc.contributor.author | Houlston, RS | |
dc.date.accessioned | 2019-02-26T12:14:42Z | |
dc.date.issued | 2019-07-01 | |
dc.identifier.citation | Annals of human genetics, 2019, 83 (4), pp. 231 - 238 | |
dc.identifier.issn | 0003-4800 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3097 | |
dc.identifier.eissn | 1469-1809 | |
dc.identifier.doi | 10.1111/ahg.12304 | |
dc.description.abstract | Genomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly different. However, one ROH at chromosome 9q21, harboring the B-cell transcription factor gene KLF9, showed evidence of a consistent association and may therefore warrant further investigation as a candidate risk factor for MM. Overall, our analysis provides little support for a homozygosity signature being a significant factor in MM risk. | |
dc.format | Print-Electronic | |
dc.format.extent | 231 - 238 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Multiple Myeloma | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Risk Assessment | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Genotype | |
dc.subject | Homozygote | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Alleles | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genetic Association Studies | |
dc.title | Regions of homozygosity as risk factors for multiple myeloma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-01-31 | |
rioxxterms.versionofrecord | 10.1111/ahg.12304 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Annals of human genetics | |
pubs.issue | 4 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/16/17 Starting Cohort | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/16/17 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 83 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Myeloma Group | |
dc.contributor.icrauthor | Went, Molly | |
dc.contributor.icrauthor | Sud, Amit | |
dc.contributor.icrauthor | Kaiser, Martin | |
dc.contributor.icrauthor | Houlston, Richard | |