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dc.contributor.authorWent, Men_US
dc.contributor.authorSud, Aen_US
dc.contributor.authorLi, Nen_US
dc.contributor.authorJohnson, DCen_US
dc.contributor.authorMitchell, JSen_US
dc.contributor.authorKaiser, Men_US
dc.contributor.authorHoulston, RSen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-02-26T12:14:42Z
dc.date.issued2019-07en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30768683en_US
dc.identifier.citationAnn Hum Genet, 2019, 83 (4), pp. 231 - 238en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3097
dc.identifier.eissn1469-1809en_US
dc.identifier.doi10.1111/ahg.12304en_US
dc.description.abstractGenomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly different. However, one ROH at chromosome 9q21, harboring the B-cell transcription factor gene KLF9, showed evidence of a consistent association and may therefore warrant further investigation as a candidate risk factor for MM. Overall, our analysis provides little support for a homozygosity signature being a significant factor in MM risk.en_US
dc.format.extent231 - 238en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectgeneticsen_US
dc.subjectmultiple myelomaen_US
dc.subjectrisk factoren_US
dc.titleRegions of homozygosity as risk factors for multiple myeloma.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-01-31en_US
rioxxterms.versionofrecord10.1111/ahg.12304en_US
rioxxterms.licenseref.startdate2019-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfAnn Hum Geneten_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.publication-statusPublisheden_US
pubs.volume83en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular & Population Geneticsen_US
icr.researchteamMyeloma Groupen_US
dc.contributor.icrauthorWent, Mollyen_US
dc.contributor.icrauthorSud, Amiten_US
dc.contributor.icrauthorKaiser, Martinen_US


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