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dc.contributor.authorWent, M
dc.contributor.authorSud, A
dc.contributor.authorLi, N
dc.contributor.authorJohnson, DC
dc.contributor.authorMitchell, JS
dc.contributor.authorKaiser, M
dc.contributor.authorHoulston, RS
dc.date.accessioned2019-02-26T12:14:42Z
dc.date.issued2019-07
dc.identifier.citationAnnals of human genetics, 2019, 83 (4), pp. 231 - 238
dc.identifier.issn0003-4800
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3097
dc.identifier.eissn1469-1809
dc.identifier.doi10.1111/ahg.12304
dc.description.abstractGenomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly different. However, one ROH at chromosome 9q21, harboring the B-cell transcription factor gene KLF9, showed evidence of a consistent association and may therefore warrant further investigation as a candidate risk factor for MM. Overall, our analysis provides little support for a homozygosity signature being a significant factor in MM risk.
dc.formatPrint-Electronic
dc.format.extent231 - 238
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectMultiple Myeloma
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectGenotype
dc.subjectHomozygote
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Association Studies
dc.titleRegions of homozygosity as risk factors for multiple myeloma.
dc.typeJournal Article
dcterms.dateAccepted2019-01-31
rioxxterms.versionofrecord10.1111/ahg.12304
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2019-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfAnnals of human genetics
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.publication-statusPublished
pubs.volume83
pubs.embargo.termsNot known
icr.researchteamCancer Genomicsen_US
icr.researchteamMyeloma Groupen_US
dc.contributor.icrauthorWent, Mollyen
dc.contributor.icrauthorSud, Amiten
dc.contributor.icrauthorKaiser, Martinen
dc.contributor.icrauthorHoulston, Richarden


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