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dc.contributor.authorTanskanen, T
dc.contributor.authorvan den Berg, L
dc.contributor.authorVälimäki, N
dc.contributor.authorAavikko, M
dc.contributor.authorNess-Jensen, E
dc.contributor.authorHveem, K
dc.contributor.authorWettergren, Y
dc.contributor.authorBexe Lindskog, E
dc.contributor.authorTõnisson, N
dc.contributor.authorMetspalu, A
dc.contributor.authorSilander, K
dc.contributor.authorOrlando, G
dc.contributor.authorLaw, PJ
dc.contributor.authorTuupanen, S
dc.contributor.authorGylfe, AE
dc.contributor.authorHänninen, UA
dc.contributor.authorCajuso, T
dc.contributor.authorKondelin, J
dc.contributor.authorSarin, A-P
dc.contributor.authorPukkala, E
dc.contributor.authorJousilahti, P
dc.contributor.authorSalomaa, V
dc.contributor.authorRipatti, S
dc.contributor.authorPalotie, A
dc.contributor.authorJärvinen, H
dc.contributor.authorRenkonen-Sinisalo, L
dc.contributor.authorLepistö, A
dc.contributor.authorBöhm, J
dc.contributor.authorMecklin, J-P
dc.contributor.authorAl-Tassan, NA
dc.contributor.authorPalles, C
dc.contributor.authorMartin, L
dc.contributor.authorBarclay, E
dc.contributor.authorTenesa, A
dc.contributor.authorFarrington, SM
dc.contributor.authorTimofeeva, MN
dc.contributor.authorMeyer, BF
dc.contributor.authorWakil, SM
dc.contributor.authorCampbell, H
dc.contributor.authorSmith, CG
dc.contributor.authorIdziaszczyk, S
dc.contributor.authorMaughan, TS
dc.contributor.authorKaplan, R
dc.contributor.authorKerr, R
dc.contributor.authorKerr, D
dc.contributor.authorBuchanan, DD
dc.contributor.authorWin, AK
dc.contributor.authorHopper, J
dc.contributor.authorJenkins, MA
dc.contributor.authorNewcomb, PA
dc.contributor.authorGallinger, S
dc.contributor.authorConti, D
dc.contributor.authorSchumacher, FR
dc.contributor.authorCasey, G
dc.contributor.authorCheadle, JP
dc.contributor.authorDunlop, MG
dc.contributor.authorTomlinson, IP
dc.contributor.authorHoulston, RS
dc.contributor.authorPalin, K
dc.contributor.authorAaltonen, LA
dc.date.accessioned2019-02-26T12:59:30Z
dc.date.issued2018-02-01
dc.identifier.citationInternational journal of cancer, 2018, 142 (3), pp. 540 - 546
dc.identifier.issn0020-7136
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3098
dc.identifier.eissn1097-0215
dc.identifier.doi10.1002/ijc.31076
dc.description.abstractGenome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 × 10-4 ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 × 10-9 ; OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate < 0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.
dc.formatPrint-Electronic
dc.format.extent540 - 546
dc.languageeng
dc.language.isoeng
dc.publisherWILEY
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRegistries
dc.subjectCase-Control Studies
dc.subjectCohort Studies
dc.subjectPolymorphism, Single Nucleotide
dc.subjectEstonia
dc.subjectFinland
dc.subjectGenome-Wide Association Study
dc.titleGenome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.
dc.typeJournal Article
dcterms.dateAccepted2017-09-01
rioxxterms.versionofrecord10.1002/ijc.31076
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of cancer
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume142
pubs.embargo.termsNot known
icr.researchteamCancer Genomics
dc.contributor.icrauthorLaw, Philip
dc.contributor.icrauthorHoulston, Richard


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