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dc.contributor.authorTanskanen, Ten_US
dc.contributor.authorvan den Berg, Len_US
dc.contributor.authorVälimäki, Nen_US
dc.contributor.authorAavikko, Men_US
dc.contributor.authorNess-Jensen, Een_US
dc.contributor.authorHveem, Ken_US
dc.contributor.authorWettergren, Yen_US
dc.contributor.authorBexe Lindskog, Een_US
dc.contributor.authorTõnisson, Nen_US
dc.contributor.authorMetspalu, Aen_US
dc.contributor.authorSilander, Ken_US
dc.contributor.authorOrlando, Gen_US
dc.contributor.authorLaw, PJen_US
dc.contributor.authorTuupanen, Sen_US
dc.contributor.authorGylfe, AEen_US
dc.contributor.authorHänninen, UAen_US
dc.contributor.authorCajuso, Ten_US
dc.contributor.authorKondelin, Jen_US
dc.contributor.authorSarin, A-Pen_US
dc.contributor.authorPukkala, Een_US
dc.contributor.authorJousilahti, Pen_US
dc.contributor.authorSalomaa, Ven_US
dc.contributor.authorRipatti, Sen_US
dc.contributor.authorPalotie, Aen_US
dc.contributor.authorJärvinen, Hen_US
dc.contributor.authorRenkonen-Sinisalo, Len_US
dc.contributor.authorLepistö, Aen_US
dc.contributor.authorBöhm, Jen_US
dc.contributor.authorMecklin, J-Pen_US
dc.contributor.authorAl-Tassan, NAen_US
dc.contributor.authorPalles, Cen_US
dc.contributor.authorMartin, Len_US
dc.contributor.authorBarclay, Een_US
dc.contributor.authorTenesa, Aen_US
dc.contributor.authorFarrington, SMen_US
dc.contributor.authorTimofeeva, MNen_US
dc.contributor.authorMeyer, BFen_US
dc.contributor.authorWakil, SMen_US
dc.contributor.authorCampbell, Hen_US
dc.contributor.authorSmith, CGen_US
dc.contributor.authorIdziaszczyk, Sen_US
dc.contributor.authorMaughan, TSen_US
dc.contributor.authorKaplan, Ren_US
dc.contributor.authorKerr, Ren_US
dc.contributor.authorKerr, Den_US
dc.contributor.authorBuchanan, DDen_US
dc.contributor.authorWin, AKen_US
dc.contributor.authorHopper, Jen_US
dc.contributor.authorJenkins, MAen_US
dc.contributor.authorNewcomb, PAen_US
dc.contributor.authorGallinger, Sen_US
dc.contributor.authorConti, Den_US
dc.contributor.authorSchumacher, FRen_US
dc.contributor.authorCasey, Gen_US
dc.contributor.authorCheadle, JPen_US
dc.contributor.authorDunlop, MGen_US
dc.contributor.authorTomlinson, IPen_US
dc.contributor.authorHoulston, RSen_US
dc.contributor.authorPalin, Ken_US
dc.contributor.authorAaltonen, LAen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2019-02-26T12:59:30Z
dc.date.issued2018-02-01en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28960316en_US
dc.identifier.citationInt J Cancer, 2018, 142 (3), pp. 540 - 546en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3098
dc.identifier.eissn1097-0215en_US
dc.identifier.doi10.1002/ijc.31076en_US
dc.description.abstractGenome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 × 10-4 ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 × 10-9 ; OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate < 0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.en_US
dc.format.extent540 - 546en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectcolorectal canceren_US
dc.subjectgenetic predisposition to diseaseen_US
dc.subjectgenome-wide association studyen_US
dc.subjectsingle-nucleotide polymorphismen_US
dc.subjectCase-Control Studiesen_US
dc.subjectCohort Studiesen_US
dc.subjectColorectal Neoplasmsen_US
dc.subjectEstoniaen_US
dc.subjectFinlanden_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenome-Wide Association Studyen_US
dc.subjectHumansen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectRegistriesen_US
dc.titleGenome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-09-01en_US
rioxxterms.versionofrecord10.1002/ijc.31076en_US
rioxxterms.licenseref.startdate2018-02-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfInt J Canceren_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.publication-statusPublisheden_US
pubs.volume142en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular & Population Geneticsen_US
dc.contributor.icrauthorLaw, Philipen_US
dc.contributor.icrauthorHoulston, Richarden_US


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