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dc.contributor.authorGarcia-Murillas, Ien_US
dc.contributor.authorTurner, NCen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-07-04T13:06:47Z
dc.date.accessioned2019-02-26T16:16:24Z
dc.date.issued2018en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29717443en_US
dc.identifier.citationMethods Mol Biol, 2018, 1768 pp. 161 - 172en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3101
dc.identifier.eissn1940-6029en_US
dc.identifier.doi10.1007/978-1-4939-7778-9_10en_US
dc.description.abstractDigital PCR (dPCR) is a highly accurate method to determine DNA concentration. In dPCR, DNA is portioned into many discrete single entities, and these are analyzed individually for the presence or absence of a target molecule of interest. Here we describe how digital PCR can be employed to determine the presence of oncogenic amplification through noninvasive analysis of circulating free DNA (cfDNA), and exemplify this approach by developing a plasma circulating free DNA dPCR assay for HER2 copy number.en_US
dc.format.extent161 - 172en_US
dc.languageengen_US
dc.language.isoengen_US
dc.relation.replaceshttps://repository.icr.ac.uk/handle/internal/1976
dc.relation.replacesinternal/1976
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.subjectBreast canceren_US
dc.subjectCirculating free DNAen_US
dc.subjectDigital PCRen_US
dc.subjectHER2en_US
dc.subjectPlasmaen_US
dc.subjectCirculating Tumor DNAen_US
dc.subjectGene Amplificationen_US
dc.subjectGene Dosageen_US
dc.subjectHumansen_US
dc.subjectNeoplasmsen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectReceptor, ErbB-2en_US
dc.titleAssessing HER2 Amplification in Plasma cfDNA.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-05-02en_US
rioxxterms.versionofrecord10.1007/978-1-4939-7778-9_10en_US
rioxxterms.licenseref.urien_US
rioxxterms.licenseref.startdate2018en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfMethods Mol Biolen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Oncology
pubs.publication-statusPublisheden_US
pubs.volume1768en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Oncologyen_US
dc.contributor.icrauthorGarcia-Murillas, Isaacen_US
dc.contributor.icrauthorTurner, Nicholasen_US


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