AXIN Shapes Tankyrase ARChitecture.
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Date
2016-10-04ICR Author
Author
Guettler, S
Type
Journal Article
Metadata
Show full item recordAbstract
The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat region of Tankyrase and discuss potential implications for enzymatic substrate modification.
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Subject
Telomere
Poly(ADP-ribose) Polymerases
Tankyrases
Adenosine Diphosphate Ribose
Ankyrins
Amino Acid Sequence
Amino Acid Motifs
Ankyrin Repeat
Axin Protein
Research team
Structural Biology of Cell Signalling
Language
eng
Date accepted
2016-09-20
License start date
2016-10
Citation
Structure (London, England : 1993), 2016, 24 (10), pp. 1625 - 1627
Publisher
CELL PRESS