dc.contributor.author | Spill, F | |
dc.contributor.author | Bakal, C | |
dc.contributor.author | Mak, M | |
dc.date.accessioned | 2019-03-06T09:37:38Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier.citation | Computational and structural biotechnology journal, 2018, 16 pp. 237 - 245 | |
dc.identifier.issn | 2001-0370 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3142 | |
dc.identifier.eissn | 2001-0370 | |
dc.identifier.doi | 10.1016/j.csbj.2018.07.002 | |
dc.description.abstract | Mechanics and biochemical signaling are both often deregulated in cancer, leading toincreased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell tension, stiffness, and engagement with the extracellular environment, which can lead to extracellular matrix remodeling. Intracellular mechanics can alter signaling and transcription factors, impacting cell decision making. Additionally, signaling from soluble and mechanical factors in the extracellular environment, such as substrate stiffness and ligand density, can modulate cytoskeletal dynamics. Computational models closely integrated with experimental support, incorporating cancer-specific parameters, can provide quantitative assessments and serve as predictive tools toward dissecting the feedback between signaling and mechanics and across multiple scales and domains in tumor progression. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 237 - 245 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Mechanical and Systems Biology of Cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-07-11 | |
rioxxterms.versionofrecord | 10.1016/j.csbj.2018.07.002 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-01 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Computational and structural biotechnology journal | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems | |
pubs.publication-status | Published | |
pubs.volume | 16 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Dynamical Cell Systems | |
dc.contributor.icrauthor | Bakal, Christopher | |