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dc.contributor.author | Guo, Q | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Canisius, S | |
dc.contributor.author | Keeman, R | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Beesley, J | |
dc.contributor.author | Lecarpentier, J | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Abraham, J | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Auer, PL | |
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dc.contributor.author | Bonanni, B | |
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dc.contributor.author | Castelao, JE | |
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dc.contributor.author | Chanock, SJ | |
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dc.contributor.author | Cheng, T-YD | |
dc.contributor.author | Chin, S-F | |
dc.contributor.author | Clarke, CL | |
dc.contributor.author | NBCS Collaborators, | |
dc.contributor.author | Cordina-Duverger, E | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, DG | |
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dc.contributor.author | Figueroa, J | |
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dc.contributor.author | Gabrielson, M | |
dc.contributor.author | Gago-Dominguez, M | |
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dc.contributor.author | Gapstur, SM | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | García-Sáenz, JA | |
dc.contributor.author | Gaudet, MM | |
dc.contributor.author | George, A | |
dc.contributor.author | Georgoulias, V | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Glendon, G | |
dc.contributor.author | Goldgar, DE | |
dc.contributor.author | González-Neira, A | |
dc.contributor.author | Alnæs, GIG | |
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dc.contributor.author | Haeberle, L | |
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dc.contributor.author | Schmidt, DF | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Schneeweiss, A | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Schumacher, F | |
dc.contributor.author | Schwentner, L | |
dc.contributor.author | Scott, RJ | |
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dc.contributor.author | Smeets, A | |
dc.contributor.author | Sohn, C | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Talhouk, A | |
dc.contributor.author | Tamimi, RM | |
dc.contributor.author | Tapper, WJ | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Tengström, M | |
dc.contributor.author | Terry, MB | |
dc.contributor.author | Thöne, K | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Torres, D | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Turman, C | |
dc.contributor.author | Turnbull, C | |
dc.contributor.author | Ulmer, H-U | |
dc.contributor.author | Untch, M | |
dc.contributor.author | Vachon, C | |
dc.contributor.author | van Asperen, CJ | |
dc.contributor.author | van den Ouweland, AMW | |
dc.contributor.author | van Veen, EM | |
dc.contributor.author | Wendt, C | |
dc.contributor.author | Whittemore, AS | |
dc.contributor.author | Willett, W | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Yang, XR | |
dc.contributor.author | Zhang, Y | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Eccles, DM | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Schmidt, MK | |
dc.date.accessioned | 2019-03-11T12:09:12Z | |
dc.date.issued | 2019-03-19 | |
dc.identifier.citation | British journal of cancer, 2019, 120 (6), pp. 647 - 657 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3149 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/s41416-019-0393-x | |
dc.description.abstract | BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10-8. For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10-7, hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10-7, HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients. | |
dc.format | Print-Electronic | |
dc.format.extent | 647 - 657 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | NBCS Collaborators | |
dc.subject | Chromosomes, Human, Pair 7 | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Receptors, Estrogen | |
dc.subject | Prognosis | |
dc.subject | Proportional Hazards Models | |
dc.subject | Bayes Theorem | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Female | |
dc.subject | Genetic Variation | |
dc.subject | Genome-Wide Association Study | |
dc.title | Genome-wide association study of germline variants and breast cancer-specific mortality. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-01-14 | |
rioxxterms.versionofrecord | 10.1038/s41416-019-0393-x | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-03 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | British journal of cancer | |
pubs.issue | 6 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published | |
pubs.volume | 120 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Turnbull, Clare | |