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dc.contributor.authorEscala-Garcia, Men_US
dc.contributor.authorGuo, Qen_US
dc.contributor.authorDörk, Ten_US
dc.contributor.authorCanisius, Sen_US
dc.contributor.authorKeeman, Ren_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorBeesley, Jen_US
dc.contributor.authorLecarpentier, Jen_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorAbraham, Jen_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorAuer, PLen_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBehrens, Sen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBermisheva, Men_US
dc.contributor.authorBernstein, Len_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorBoeckx, Ben_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBonanni, Ben_US
dc.contributor.authorBørresen-Dale, A-Len_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorBrentnall, Aen_US
dc.contributor.authorBrinton, Len_US
dc.contributor.authorBroberg, Pen_US
dc.contributor.authorBrock, IWen_US
dc.contributor.authorBrucker, SYen_US
dc.contributor.authorBurwinkel, Ben_US
dc.contributor.authorCaldas, Cen_US
dc.contributor.authorCaldés, Ten_US
dc.contributor.authorCampa, Den_US
dc.contributor.authorCanzian, Fen_US
dc.contributor.authorCarracedo, Aen_US
dc.contributor.authorCarter, BDen_US
dc.contributor.authorCastelao, JEen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorCheng, T-YDen_US
dc.contributor.authorChin, S-Fen_US
dc.contributor.authorClarke, CLen_US
dc.contributor.authorNBCS Collaboratorsen_US
dc.contributor.authorCordina-Duverger, Een_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorCox, DGen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorDaly, MBen_US
dc.contributor.authorDevilee, Pen_US
dc.contributor.authorDunn, JAen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorDurcan, Len_US
dc.contributor.authorDwek, Men_US
dc.contributor.authorEarl, HMen_US
dc.contributor.authorEkici, ABen_US
dc.contributor.authorEliassen, AHen_US
dc.contributor.authorEllberg, Cen_US
dc.contributor.authorEngel, Cen_US
dc.contributor.authorEriksson, Men_US
dc.contributor.authorEvans, DGen_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorFlesch-Janys, Den_US
dc.contributor.authorFlyger, Hen_US
dc.contributor.authorGabrielson, Men_US
dc.contributor.authorGago-Dominguez, Men_US
dc.contributor.authorGalle, Een_US
dc.contributor.authorGapstur, SMen_US
dc.contributor.authorGarcía-Closas, Men_US
dc.contributor.authorGarcía-Sáenz, JAen_US
dc.contributor.authorGaudet, MMen_US
dc.contributor.authorGeorge, Aen_US
dc.contributor.authorGeorgoulias, Ven_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGlendon, Gen_US
dc.contributor.authorGoldgar, DEen_US
dc.contributor.authorGonzález-Neira, Aen_US
dc.contributor.authorAlnæs, GIGen_US
dc.contributor.authorGrip, Men_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorHaeberle, Len_US
dc.contributor.authorHahnen, Een_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorHåkansson, Nen_US
dc.contributor.authorHall, Pen_US
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dc.contributor.authorHankinson, Sen_US
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dc.contributor.authorHein, Aen_US
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dc.contributor.authorHiller, Len_US
dc.contributor.authorHolleczek, Ben_US
dc.contributor.authorHollestelle, Aen_US
dc.contributor.authorHooning, MJen_US
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dc.contributor.authorHopper, JLen_US
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dc.contributor.authorHuang, Gen_US
dc.contributor.authorHumphreys, Ken_US
dc.contributor.authorHunter, DJen_US
dc.contributor.authorJanni, Wen_US
dc.contributor.authorJohn, EMen_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorJukkola-Vuorinen, Aen_US
dc.contributor.authorJung, Aen_US
dc.contributor.authorKaaks, Ren_US
dc.contributor.authorKabisch, Men_US
dc.contributor.authorKaczmarek, Ken_US
dc.contributor.authorKerin, MJen_US
dc.contributor.authorKhan, Sen_US
dc.contributor.authorKhusnutdinova, Een_US
dc.contributor.authorKiiski, JIen_US
dc.contributor.authorKitahara, CMen_US
dc.contributor.authorKnight, JAen_US
dc.contributor.authorKo, Y-Den_US
dc.contributor.authorKoppert, LBen_US
dc.contributor.authorKosma, V-Men_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorKristensen, VNen_US
dc.contributor.authorKrüger, Uen_US
dc.contributor.authorKühl, Ten_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorLee, Een_US
dc.contributor.authorLejbkowicz, Fen_US
dc.contributor.authorLi, Len_US
dc.contributor.authorLindblom, Aen_US
dc.contributor.authorLindström, Sen_US
dc.contributor.authorLinet, Men_US
dc.contributor.authorLissowska, Jen_US
dc.contributor.authorLo, W-Yen_US
dc.contributor.authorLoibl, Sen_US
dc.contributor.authorLubiński, Jen_US
dc.contributor.authorLux, MPen_US
dc.contributor.authorMacInnis, RJen_US
dc.contributor.authorMaierthaler, Men_US
dc.contributor.authorMaishman, Ten_US
dc.contributor.authorMakalic, Een_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorManoochehri, Men_US
dc.contributor.authorManoukian, Sen_US
dc.contributor.authorMargolin, Sen_US
dc.contributor.authorMartinez, MEen_US
dc.contributor.authorMavroudis, Den_US
dc.contributor.authorMcLean, Cen_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorMiddha, Pen_US
dc.contributor.authorMiller, Nen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorMoreno, Fen_US
dc.contributor.authorMulligan, AMen_US
dc.contributor.authorMulot, Cen_US
dc.contributor.authorNassir, Ren_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorNewman, WTen_US
dc.contributor.authorNielsen, SFen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorNorman, Aen_US
dc.contributor.authorOlsson, Hen_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorPankratz, VSen_US
dc.contributor.authorPark-Simon, T-Wen_US
dc.contributor.authorPerez, JIAen_US
dc.contributor.authorPérez-Barrios, Cen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorPetridis, Cen_US
dc.contributor.authorPinchev, Men_US
dc.contributor.authorPrajzendanc, Ken_US
dc.contributor.authorPrentice, Ren_US
dc.contributor.authorPresneau, Nen_US
dc.contributor.authorProkofieva, Den_US
dc.contributor.authorPylkäs, Ken_US
dc.contributor.authorRack, Ben_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorRamachandran, Den_US
dc.contributor.authorRennert, Gen_US
dc.contributor.authorRennert, HSen_US
dc.contributor.authorRhenius, Ven_US
dc.contributor.authorRomero, Aen_US
dc.contributor.authorRoylance, Ren_US
dc.contributor.authorSaloustros, Een_US
dc.contributor.authorSawyer, EJen_US
dc.contributor.authorSchmidt, DFen_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorSchneeweiss, Aen_US
dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorSchumacher, Fen_US
dc.contributor.authorSchwentner, Len_US
dc.contributor.authorScott, RJen_US
dc.contributor.authorScott, Cen_US
dc.contributor.authorSeynaeve, Cen_US
dc.contributor.authorShah, Men_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorSmeets, Aen_US
dc.contributor.authorSohn, Cen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorSwerdlow, AJen_US
dc.contributor.authorTalhouk, Aen_US
dc.contributor.authorTamimi, RMen_US
dc.contributor.authorTapper, WJen_US
dc.contributor.authorTeixeira, MRen_US
dc.contributor.authorTengström, Men_US
dc.contributor.authorTerry, MBen_US
dc.contributor.authorThöne, Ken_US
dc.contributor.authorTollenaar, RAEMen_US
dc.contributor.authorTomlinson, Ien_US
dc.contributor.authorTorres, Den_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorTurman, Cen_US
dc.contributor.authorTurnbull, Cen_US
dc.contributor.authorUlmer, H-Uen_US
dc.contributor.authorUntch, Men_US
dc.contributor.authorVachon, Cen_US
dc.contributor.authorvan Asperen, CJen_US
dc.contributor.authorvan den Ouweland, AMWen_US
dc.contributor.authorvan Veen, EMen_US
dc.contributor.authorWendt, Cen_US
dc.contributor.authorWhittemore, ASen_US
dc.contributor.authorWillett, Wen_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorWolk, Aen_US
dc.contributor.authorYang, XRen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorEccles, DMen_US
dc.contributor.authorPharoah, PDPen_US
dc.contributor.authorSchmidt, MKen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-03-11T12:09:12Z
dc.date.issued2019-03en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30787463en_US
dc.identifier10.1038/s41416-019-0393-xen_US
dc.identifier.citationBr J Cancer, 2019, 120 (6), pp. 647 - 657en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3149
dc.identifier.eissn1532-1827en_US
dc.identifier.doi10.1038/s41416-019-0393-xen_US
dc.description.abstractBACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10-8. For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10-7, hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10-7, HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.en_US
dc.format.extent647 - 657en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleGenome-wide association study of germline variants and breast cancer-specific mortality.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-01-14en_US
rioxxterms.versionofrecord10.1038/s41416-019-0393-xen_US
rioxxterms.licenseref.startdate2019-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBr J Canceren_US
pubs.issue6en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublisheden_US
pubs.volume120en_US
pubs.embargo.termsNot knownen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorJones, Michaelen_US


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