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dc.contributor.authorZhu, Y
dc.contributor.authorWei, Y
dc.contributor.authorZhang, R
dc.contributor.authorDong, X
dc.contributor.authorShen, S
dc.contributor.authorZhao, Y
dc.contributor.authorBai, J
dc.contributor.authorAlbanes, D
dc.contributor.authorCaporaso, NE
dc.contributor.authorLandi, MT
dc.contributor.authorZhu, B
dc.contributor.authorChanock, SJ
dc.contributor.authorGu, F
dc.contributor.authorLam, S
dc.contributor.authorTsao, M-S
dc.contributor.authorShepherd, FA
dc.contributor.authorTardon, A
dc.contributor.authorFernández-Somoano, A
dc.contributor.authorFernandez-Tardon, G
dc.contributor.authorChen, C
dc.contributor.authorBarnett, MJ
dc.contributor.authorDoherty, J
dc.contributor.authorBojesen, SE
dc.contributor.authorJohansson, M
dc.contributor.authorBrennan, P
dc.contributor.authorMcKay, JD
dc.contributor.authorCarreras-Torres, R
dc.contributor.authorMuley, T
dc.contributor.authorRisch, A
dc.contributor.authorWichmann, H-E
dc.contributor.authorBickeboeller, H
dc.contributor.authorRosenberger, A
dc.contributor.authorRennert, G
dc.contributor.authorSaliba, W
dc.contributor.authorArnold, SM
dc.contributor.authorField, JK
dc.contributor.authorDavies, MPA
dc.contributor.authorMarcus, MW
dc.contributor.authorWu, X
dc.contributor.authorYe, Y
dc.contributor.authorLe Marchand, L
dc.contributor.authorWilkens, LR
dc.contributor.authorMelander, O
dc.contributor.authorManjer, J
dc.contributor.authorBrunnström, H
dc.contributor.authorHung, RJ
dc.contributor.authorLiu, G
dc.contributor.authorBrhane, Y
dc.contributor.authorKachuri, L
dc.contributor.authorAndrew, AS
dc.contributor.authorDuell, EJ
dc.contributor.authorKiemeney, LA
dc.contributor.authorvan der Heijden, EH
dc.contributor.authorHaugen, A
dc.contributor.authorZienolddiny, S
dc.contributor.authorSkaug, V
dc.contributor.authorGrankvist, K
dc.contributor.authorJohansson, M
dc.contributor.authorWoll, PJ
dc.contributor.authorCox, A
dc.contributor.authorTaylor, F
dc.contributor.authorTeare, DM
dc.contributor.authorLazarus, P
dc.contributor.authorSchabath, MB
dc.contributor.authorAldrich, MC
dc.contributor.authorHoulston, RS
dc.contributor.authorMcLaughlin, J
dc.contributor.authorStevens, VL
dc.contributor.authorShen, H
dc.contributor.authorHu, Z
dc.contributor.authorDai, J
dc.contributor.authorAmos, CI
dc.contributor.authorHan, Y
dc.contributor.authorZhu, D
dc.contributor.authorGoodman, GE
dc.contributor.authorChen, F
dc.contributor.authorChristiani, DC
dc.date.accessioned2019-04-10T11:29:46Z
dc.date.issued2019-05-01
dc.identifier.citationCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019, 28 (5), pp. 935 - 942
dc.identifier.issn1055-9965
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3179
dc.identifier.eissn1538-7755
dc.identifier.doi10.1158/1055-9965.epi-18-0356
dc.description.abstractBACKGROUND: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. METHODS: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. RESULTS: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non-small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. CONCLUSIONS: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. IMPACT: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.
dc.formatPrint-Electronic
dc.format.extent935 - 942
dc.languageeng
dc.language.isoeng
dc.publisherAMER ASSOC CANCER RESEARCH
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectBlood Platelets
dc.subjectHumans
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectCarcinoma, Squamous Cell
dc.subjectLung Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectPlatelet Count
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectPolymorphism, Single Nucleotide
dc.subjectSmall Cell Lung Carcinoma
dc.subjectMendelian Randomization Analysis
dc.subjectBiomarkers, Tumor
dc.subjectAdenocarcinoma of Lung
dc.titleElevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.
dc.typeJournal Article
dcterms.dateAccepted2019-01-17
rioxxterms.versionofrecord10.1158/1055-9965.epi-18-0356
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2019-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
pubs.issue5
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume28
pubs.embargo.termsNot known
icr.researchteamCancer Genomics
dc.contributor.icrauthorHoulston, Richard


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