Show simple item record

dc.contributor.authorZhu, Yen_US
dc.contributor.authorWei, Yen_US
dc.contributor.authorZhang, Ren_US
dc.contributor.authorDong, Xen_US
dc.contributor.authorShen, Sen_US
dc.contributor.authorZhao, Yen_US
dc.contributor.authorBai, Jen_US
dc.contributor.authorAlbanes, Den_US
dc.contributor.authorCaporaso, NEen_US
dc.contributor.authorLandi, MTen_US
dc.contributor.authorZhu, Ben_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorGu, Fen_US
dc.contributor.authorLam, Sen_US
dc.contributor.authorTsao, M-Sen_US
dc.contributor.authorShepherd, FAen_US
dc.contributor.authorTardon, Aen_US
dc.contributor.authorFernández-Somoano, Aen_US
dc.contributor.authorFernandez-Tardon, Gen_US
dc.contributor.authorChen, Cen_US
dc.contributor.authorBarnett, MJen_US
dc.contributor.authorDoherty, Jen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorJohansson, Men_US
dc.contributor.authorBrennan, Pen_US
dc.contributor.authorMcKay, JDen_US
dc.contributor.authorCarreras-Torres, Ren_US
dc.contributor.authorMuley, Ten_US
dc.contributor.authorRisch, Aen_US
dc.contributor.authorWichmann, H-Een_US
dc.contributor.authorBickeboeller, Hen_US
dc.contributor.authorRosenberger, Aen_US
dc.contributor.authorRennert, Gen_US
dc.contributor.authorSaliba, Wen_US
dc.contributor.authorArnold, SMen_US
dc.contributor.authorField, JKen_US
dc.contributor.authorDavies, MPAen_US
dc.contributor.authorMarcus, MWen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorYe, Yen_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorWilkens, LRen_US
dc.contributor.authorMelander, Oen_US
dc.contributor.authorManjer, Jen_US
dc.contributor.authorBrunnström, Hen_US
dc.contributor.authorHung, RJen_US
dc.contributor.authorLiu, Gen_US
dc.contributor.authorBrhane, Yen_US
dc.contributor.authorKachuri, Len_US
dc.contributor.authorAndrew, ASen_US
dc.contributor.authorDuell, EJen_US
dc.contributor.authorKiemeney, LAen_US
dc.contributor.authorvan der Heijden, EHen_US
dc.contributor.authorHaugen, Aen_US
dc.contributor.authorZienolddiny, Sen_US
dc.contributor.authorSkaug, Ven_US
dc.contributor.authorGrankvist, Ken_US
dc.contributor.authorJohansson, Men_US
dc.contributor.authorWoll, PJen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorTaylor, Fen_US
dc.contributor.authorTeare, DMen_US
dc.contributor.authorLazarus, Pen_US
dc.contributor.authorSchabath, MBen_US
dc.contributor.authorAldrich, MCen_US
dc.contributor.authorHoulston, RSen_US
dc.contributor.authorMcLaughlin, Jen_US
dc.contributor.authorStevens, VLen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorHu, Zen_US
dc.contributor.authorDai, Jen_US
dc.contributor.authorAmos, CIen_US
dc.contributor.authorHan, Yen_US
dc.contributor.authorZhu, Den_US
dc.contributor.authorGoodman, GEen_US
dc.contributor.authorChen, Fen_US
dc.contributor.authorChristiani, DCen_US
dc.date.accessioned2019-04-10T11:29:46Z
dc.date.issued2019-05en_US
dc.identifier.citationCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019, 28 (5), pp. 935 - 942en_US
dc.identifier.issn1055-9965en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3179
dc.identifier.eissn1538-7755en_US
dc.identifier.doi10.1158/1055-9965.epi-18-0356en_US
dc.description.abstract<h4>Background</h4>Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear.<h4>Methods</h4>We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk.<h4>Results</h4>Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non-small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; <i>P</i> = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; <i>P</i> = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings.<h4>Conclusions</h4>Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention.<h4>Impact</h4>These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.en_US
dc.formatPrint-Electronicen_US
dc.format.extent935 - 942en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.subjectBlood Plateletsen_US
dc.subjectHumansen_US
dc.subjectCarcinoma, Non-Small-Cell Lungen_US
dc.subjectCarcinoma, Squamous Cellen_US
dc.subjectLung Neoplasmsen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectPlatelet Counten_US
dc.subjectPrognosisen_US
dc.subjectRisk Factorsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectSmall Cell Lung Carcinomaen_US
dc.subjectMendelian Randomization Analysisen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectAdenocarcinoma of Lungen_US
dc.titleElevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-01-17en_US
rioxxterms.versionofrecord10.1158/1055-9965.epi-18-0356en_US
rioxxterms.licenseref.startdate2019-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyen_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublisheden_US
pubs.volume28en_US
pubs.embargo.termsNot knownen_US
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorHoulston, Richarden_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record