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dc.contributor.authorChattopadhyay, S
dc.contributor.authorZheng, G
dc.contributor.authorSud, A
dc.contributor.authorSundquist, K
dc.contributor.authorSundquist, J
dc.contributor.authorFörsti, A
dc.contributor.authorHoulston, R
dc.contributor.authorHemminki, A
dc.contributor.authorHemminki, K
dc.date.accessioned2019-04-29T13:59:11Z
dc.date.issued2020-02
dc.identifier.citationInternational journal of cancer, 2020, 146 (4), pp. 970 - 976
dc.identifier.issn0020-7136
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3208
dc.identifier.eissn1097-0215
dc.identifier.doi10.1002/ijc.32391
dc.description.abstractSecond primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family-Cancer Database on non-Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. NHL patients were identified from the years 1958 to 2015 and generalized Poisson models were used to calculate relative risks (RRs) for SPCs and familial SPCs. Among 14,393 NHL patients, a total of 1,866 (13.0%) were diagnosed with SPC. Familial risk of nine particular cancers was associated with risks of these cancers as SPCs, with twofold to fivefold increase in RRs. At the end of a 25-year follow-up period, the survival probability for persons with SPC was only 20% of that for patients without SPC; the hazard ratio for SPC was 1.59 (95% CI: 1.46-1.72). Survival could be predicted by the prognostic groups based on first cancers and HRs increase systematically with worse prognosis yielding a trend of p = 4.6 × 10-5 . SPCs had deleterious consequences for survival in NHL patients. Family history was associated with increasing numbers of SPCs. Prevention of SPCs and their early detection is an important target in the overall strategy to improve survival in NHL patients. Counseling for avoidance of risk factors and targeted screening based on family history are feasible steps in risk reduction.
dc.formatPrint-Electronic
dc.format.extent970 - 976
dc.languageeng
dc.language.isoeng
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectLymphoma, Non-Hodgkin
dc.subjectNeoplasms, Second Primary
dc.subjectDatabases, Factual
dc.subjectMiddle Aged
dc.subjectFamily Health
dc.subjectSweden
dc.subjectFemale
dc.subjectMale
dc.subjectKaplan-Meier Estimate
dc.titleSecond primary cancers in non-Hodgkin lymphoma: Family history and survival.
dc.typeJournal Article
dcterms.dateAccepted2019-04-24
rioxxterms.versionofrecord10.1002/ijc.32391
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of cancer
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume146
pubs.embargo.termsNot known
icr.researchteamCancer Genomics
dc.contributor.icrauthorSud, Amit
dc.contributor.icrauthorHoulston, Richard


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