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dc.contributor.authorChabanon, RMen_US
dc.contributor.authorSoria, J-Cen_US
dc.contributor.authorLord, CJen_US
dc.contributor.authorPostel-Vinay, Sen_US
dc.date.accessioned2019-06-04T09:47:36Z
dc.date.issued2019-01
dc.identifier.citationMolecular & cellular oncology, 2019, 6 (2), pp. 1585170 - ?
dc.identifier.issn2372-3556
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3248
dc.identifier.eissn2372-3556
dc.identifier.doi10.1080/23723556.2019.1585170
dc.description.abstractLoss of excision repair cross-complementation group 1 (ERCC1), frequently found in lung cancer, and mutations in breast cancer type 1/2 susceptibility genes ( BRCA1/2 ), often found in ovarian, breast and prostate cancers, confer sensitivity to poly-(ADP-ribose) polymerase inhibitors (PARPi). Our work, and that of others, shows that PARPi selectively trigger tumor cell-autonomous immune phenotypes in ERCC1- or BRCA -defective contexts. This suggests that PARPi, used in appropriately selected populations, might mediate their therapeutic effects by potentiating anti-tumor immunity.
dc.formatElectronic-eCollection
dc.format.extent1585170 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleBeyond DNA repair: the novel immunological potential of PARP inhibitors.
dc.typeJournal Article
dcterms.dateAccepted2019-02-18
rioxxterms.versionofrecord10.1080/23723556.2019.1585170
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2019-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMolecular & cellular oncology
pubs.issue2
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.publication-statusPublished
pubs.volume6
pubs.embargo.termsNo embargo
icr.researchteamGene Functionen_US
dc.contributor.icrauthorLord, Christopheren


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