From Clinical Trials to Real-life Clinical Practice: The Role of Immunotherapy with PD-1/PD-L1 Inhibitors in Advanced Urothelial Carcinoma.
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Date
2018-12-01ICR Author
Author
Hussain, SA
Birtle, A
Crabb, S
Huddart, R
Small, D
Summerhayes, M
Jones, R
Protheroe, A
Type
Journal Article
Metadata
Show full item recordAbstract
CONTEXT: A number of PD-1/PD-L1 inhibitors have recently been approved for use in patients with locally advanced or metastatic urothelial carcinoma (UC) on the basis of results from several clinical trials. OBJECTIVE: To review the evidence from these trials and consider what it means for the use of these drugs in first-line and post-platinum settings in real-life clinical practice. EVIDENCE ACQUISITION: PubMed was searched for full reports of clinical trials of single-agent PD-1/PD-L1 inhibitors in advanced UC. Twelve publications were included. EVIDENCE SYNTHESIS: Responses to PD-1/PD-L1 inhibitors appear to be durable but are only achieved in 17-26% of patients. These drugs offer different toxicity and efficacy profiles to standard chemotherapy regimens. This should be considered when choosing a treatment strategy for each patient. CONCLUSIONS: PD-1/PD-L1 inhibitors represent a major step forward in the management of advanced UC, although several questions remain regarding their optimal use in routine clinical practice. A validated predictive biomarker of response is yet to be defined, and this is perhaps the most significant unmet need for currently available drugs. PATIENT SUMMARY: We reviewed the results from clinical trials that investigated how well certain types of anticancer drugs called PD-1/PD-L1 inhibitors worked in patients with bladder cancer. We found that more research is required to identify (1) the factors that might predict which patients with bladder cancer will respond to PD-1/PD-L1 inhibitors and (2) the optimum duration of treatment with these drugs.
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Subject
Humans
Urologic Neoplasms
Cisplatin
Antibodies, Monoclonal
Immunotherapy
Urinary Bladder Neoplasms
Clinical Trials as Topic
Antibodies, Monoclonal, Humanized
Programmed Cell Death 1 Receptor
Antineoplastic Agents, Immunological
Ipilimumab
B7-H1 Antigen
Research team
Clinical Academic Radiotherapy (Huddart)
Language
eng
Date accepted
2018-05-30
License start date
2018-12
Citation
European urology oncology, 2018, 1 (6), pp. 486 - 500
Publisher
ELSEVIER