Show simple item record

dc.contributor.authorSonnenblick, Aen_US
dc.contributor.authorBailey, Aen_US
dc.contributor.authorUziely, Ben_US
dc.contributor.authorUntch, Men_US
dc.contributor.authorSmith, Ien_US
dc.contributor.authorGianni, Len_US
dc.contributor.authorBaselga, Jen_US
dc.contributor.authorJackisch, Cen_US
dc.contributor.authorCameron, Den_US
dc.contributor.authorBell, Ren_US
dc.contributor.authorZardavas, Den_US
dc.contributor.authorAl-Sakaff, Nen_US
dc.contributor.authorGelber, RDen_US
dc.contributor.authorDowsett, Men_US
dc.contributor.authorLeyland-Jones, Ben_US
dc.contributor.authorPiccart-Gebhart, MJen_US
dc.contributor.authorDE Azambuja, Een_US
dc.coverage.spatialGreeceen_US
dc.date.accessioned2019-07-04T12:47:04Z
dc.date.issued2019-02en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30711959en_US
dc.identifier39/2/797en_US
dc.identifier.citationAnticancer Res, 2019, 39 (2), pp. 797 - 802en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3281
dc.identifier.eissn1791-7530en_US
dc.identifier.doi10.21873/anticanres.13177en_US
dc.description.abstractBACKGROUND/AIM: This study sought to determine whether an autoimmune background could identify patients with HER2-positive early breast cancer (EBC) who derive differential benefit from primary adjuvant trastuzumab-based therapy. PATIENTS AND METHODS: HERA is an international randomized trial of 5,102 women with HER2-positive EBC, who were enrolled to either receive adjuvant trastuzumab or not. In this exploratory analysis, the interaction between autoimmune history and the magnitude of trastuzumab benefit was evaluated. RESULTS: A total of 5,099 patients were included in the current analysis. Among them, 325 patients (6.4%) had autoimmune disease history, 295 of whom had active disease. Patients were randomly assigned to trastuzumab or no-trastuzumab groups. Similar reductions in the risk of events in patients with and without autoimmune history were observed (interaction p=0.95 for disease-free survival, and p=0.62 for overall survival). CONCLUSION: No evidence of a differential benefit from trastuzumab in patients with a medical history of autoimmune disease was found.en_US
dc.format.extent797 - 802en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectAutoimmunityen_US
dc.subjectHER2en_US
dc.subjectbreast canceren_US
dc.subjecttrastuzumaben_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAntineoplastic Agents, Immunologicalen_US
dc.subjectAutoimmune Diseasesen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectChemotherapy, Adjuvanten_US
dc.subjectDisease-Free Survivalen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectInternational Cooperationen_US
dc.subjectMiddle Ageden_US
dc.subjectProportional Hazards Modelsen_US
dc.subjectRisken_US
dc.subjectTrastuzumaben_US
dc.subjectTreatment Outcomeen_US
dc.titleAutoimmunity and Benefit from Trastuzumab Treatment in Breast Cancer: Results from the HERA Trial.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-01-10en_US
rioxxterms.versionofrecord10.21873/anticanres.13177en_US
rioxxterms.licenseref.startdate2019-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfAnticancer Resen_US
pubs.issue2en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.)
pubs.publication-statusPublisheden_US
pubs.volume39en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamEndocrinologyen_US
dc.contributor.icrauthorDowsett, Mitchen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record