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dc.contributor.authorFerreira, MA
dc.contributor.authorGamazon, ER
dc.contributor.authorAl-Ejeh, F
dc.contributor.authorAittomäki, K
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArason, A
dc.contributor.authorArndt, V
dc.contributor.authorAronson, KJ
dc.contributor.authorArun, BK
dc.contributor.authorAsseryanis, E
dc.contributor.authorAzzollini, J
dc.contributor.authorBalmaña, J
dc.contributor.authorBarnes, DR
dc.contributor.authorBarrowdale, D
dc.contributor.authorBeckmann, MW
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBiałkowska, K
dc.contributor.authorBlomqvist, C
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBolla, MK
dc.contributor.authorBorg, A
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBroeks, A
dc.contributor.authorBurwinkel, B
dc.contributor.authorCaldés, T
dc.contributor.authorCaligo, MA
dc.contributor.authorCampa, D
dc.contributor.authorCampbell, I
dc.contributor.authorCanzian, F
dc.contributor.authorCarter, J
dc.contributor.authorCarter, BD
dc.contributor.authorCastelao, JE
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, SJ
dc.contributor.authorChristiansen, H
dc.contributor.authorChung, WK
dc.contributor.authorClaes, KBM
dc.contributor.authorClarke, CL
dc.contributor.authorEMBRACE Collaborators
dc.contributor.authorGC-HBOC Study Collaborators
dc.contributor.authorGEMO Study Collaborators
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDaly, MB
dc.contributor.authorde la Hoya, M
dc.contributor.authorDennis, J
dc.contributor.authorDevilee, P
dc.contributor.authorDiez, O
dc.contributor.authorDörk, T
dc.contributor.authorDunning, AM
dc.contributor.authorDwek, M
dc.contributor.authorEccles, DM
dc.contributor.authorEjlertsen, B
dc.contributor.authorEllberg, C
dc.contributor.authorEngel, C
dc.contributor.authorEriksson, M
dc.contributor.authorFasching, PA
dc.contributor.authorFletcher, O
dc.contributor.authorFlyger, H
dc.contributor.authorFriedman, E
dc.contributor.authorFrost, D
dc.contributor.authorGabrielson, M
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGanz, PA
dc.contributor.authorGapstur, SM
dc.contributor.authorGarber, J
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGarcía-Sáenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGiles, GG
dc.contributor.authorGlendon, G
dc.contributor.authorGodwin, AK
dc.contributor.authorGoldberg, MS
dc.contributor.authorGoldgar, DE
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorGreene, MH
dc.contributor.authorGronwald, J
dc.contributor.authorGuénel, P
dc.contributor.authorHaiman, CA
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHe, W
dc.contributor.authorHeyworth, J
dc.contributor.authorHogervorst, FBL
dc.contributor.authorHollestelle, A
dc.contributor.authorHoover, RN
dc.contributor.authorHopper, JL
dc.contributor.authorHulick, PJ
dc.contributor.authorHumphreys, K
dc.contributor.authorImyanitov, EN
dc.contributor.authorABCTB Investigators
dc.contributor.authorHEBON Investigators
dc.contributor.authorBCFR Investigators
dc.contributor.authorIsaacs, C
dc.contributor.authorJakimovska, M
dc.contributor.authorJakubowska, A
dc.contributor.authorJames, PA
dc.contributor.authorJanavicius, R
dc.contributor.authorJankowitz, RC
dc.contributor.authorJohn, EM
dc.contributor.authorJohnson, N
dc.contributor.authorJoseph, V
dc.contributor.authorKarlan, BY
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKiiski, JI
dc.contributor.authorKo, Y-D
dc.contributor.authorJones, ME
dc.contributor.authorKonstantopoulou, I
dc.contributor.authorKristensen, VN
dc.contributor.authorLaitman, Y
dc.contributor.authorLambrechts, D
dc.contributor.authorLazaro, C
dc.contributor.authorLeslie, G
dc.contributor.authorLester, J
dc.contributor.authorLesueur, F
dc.contributor.authorLindström, S
dc.contributor.authorLong, J
dc.contributor.authorLoud, JT
dc.contributor.authorLubiński, J
dc.contributor.authorMakalic, E
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorMargolin, S
dc.contributor.authorMaurer, T
dc.contributor.authorMavroudis, D
dc.contributor.authorMcGuffog, L
dc.contributor.authorMeindl, A
dc.contributor.authorMenon, U
dc.contributor.authorMichailidou, K
dc.contributor.authorMiller, A
dc.contributor.authorMontagna, M
dc.contributor.authorMoreno, F
dc.contributor.authorMoserle, L
dc.contributor.authorMulligan, AM
dc.contributor.authorNathanson, KL
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNevelsteen, I
dc.contributor.authorNielsen, FC
dc.contributor.authorNikitina-Zake, L
dc.contributor.authorNussbaum, RL
dc.contributor.authorOffit, K
dc.contributor.authorOlah, E
dc.contributor.authorOlopade, OI
dc.contributor.authorOlsson, H
dc.contributor.authorOsorio, A
dc.contributor.authorPapp, J
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorParsons, MT
dc.contributor.authorPedersen, IS
dc.contributor.authorPeixoto, A
dc.contributor.authorPeterlongo, P
dc.contributor.authorPharoah, PDP
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPoppe, B
dc.contributor.authorPresneau, N
dc.contributor.authorRadice, P
dc.contributor.authorRantala, J
dc.contributor.authorRennert, G
dc.contributor.authorRisch, HA
dc.contributor.authorSaloustros, E
dc.contributor.authorSanden, K
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmidt, MK
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSharma, P
dc.contributor.authorShu, X-O
dc.contributor.authorSimard, J
dc.contributor.authorSinger, CF
dc.contributor.authorSoucy, P
dc.contributor.authorSouthey, MC
dc.contributor.authorSpinelli, JJ
dc.contributor.authorSpurdle, AB
dc.contributor.authorStone, J
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTapper, WJ
dc.contributor.authorTaylor, JA
dc.contributor.authorTeixeira, MR
dc.contributor.authorTerry, MB
dc.contributor.authorTeulé, A
dc.contributor.authorThomassen, M
dc.contributor.authorThöne, K
dc.contributor.authorThull, DL
dc.contributor.authorTischkowitz, M
dc.contributor.authorToland, AE
dc.contributor.authorTorres, D
dc.contributor.authorTruong, T
dc.contributor.authorTung, N
dc.contributor.authorVachon, CM
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorvan den Ouweland, AMW
dc.contributor.authorvan Rensburg, EJ
dc.contributor.authorVega, A
dc.contributor.authorViel, A
dc.contributor.authorWang, Q
dc.contributor.authorWappenschmidt, B
dc.contributor.authorWeitzel, JN
dc.contributor.authorWendt, C
dc.contributor.authorWinqvist, R
dc.contributor.authorYang, XR
dc.contributor.authorYannoukakos, D
dc.contributor.authorZiogas, A
dc.contributor.authorKraft, P
dc.contributor.authorAntoniou, AC
dc.contributor.authorZheng, W
dc.contributor.authorEaston, DF
dc.contributor.authorMilne, RL
dc.contributor.authorBeesley, J
dc.contributor.authorChenevix-Trench, G
dc.date.accessioned2019-07-05T13:42:05Z
dc.date.issued2019-04-15
dc.identifier.citationNature communications, 2019, 10 (1), pp. 1741 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3284
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-018-08053-5
dc.description.abstractGenome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
dc.formatElectronic
dc.format.extent1741 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectEMBRACE Collaborators
dc.subjectGC-HBOC Study Collaborators
dc.subjectGEMO Study Collaborators
dc.subjectABCTB Investigators
dc.subjectHEBON Investigators
dc.subjectBCFR Investigators
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectGene Expression Profiling
dc.subjectQuantitative Trait Loci
dc.subjectFemale
dc.subjectGenome-Wide Association Study
dc.titleGenome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.
dc.typeJournal Article
dcterms.dateAccepted2018-12-14
rioxxterms.versionofrecord10.1038/s41467-018-08053-5
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2019-04-15
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume10
pubs.embargo.termsNot known
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorFletcher, Oliviaen
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorJones, Michaelen


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