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dc.contributor.authorFerreira, MAen_US
dc.contributor.authorGamazon, ERen_US
dc.contributor.authorAl-Ejeh, Fen_US
dc.contributor.authorAittomäki, Ken_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorArason, Aen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorAronson, KJen_US
dc.contributor.authorArun, BKen_US
dc.contributor.authorAsseryanis, Een_US
dc.contributor.authorAzzollini, Jen_US
dc.contributor.authorBalmaña, Jen_US
dc.contributor.authorBarnes, DRen_US
dc.contributor.authorBarrowdale, Den_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBehrens, Sen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBermisheva, Men_US
dc.contributor.authorBiałkowska, Ken_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorBogdanova, NVen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorBorg, Aen_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorBroeks, Aen_US
dc.contributor.authorBurwinkel, Ben_US
dc.contributor.authorCaldés, Ten_US
dc.contributor.authorCaligo, MAen_US
dc.contributor.authorCampa, Den_US
dc.contributor.authorCampbell, Ien_US
dc.contributor.authorCanzian, Fen_US
dc.contributor.authorCarter, Jen_US
dc.contributor.authorCarter, BDen_US
dc.contributor.authorCastelao, JEen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorChristiansen, Hen_US
dc.contributor.authorChung, WKen_US
dc.contributor.authorClaes, KBMen_US
dc.contributor.authorClarke, CLen_US
dc.contributor.authorEMBRACE Collaboratorsen_US
dc.contributor.authorGC-HBOC Study Collaboratorsen_US
dc.contributor.authorGEMO Study Collaboratorsen_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorDaly, MBen_US
dc.contributor.authorde la Hoya, Men_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorDevilee, Pen_US
dc.contributor.authorDiez, Oen_US
dc.contributor.authorDörk, Ten_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorDwek, Men_US
dc.contributor.authorEccles, DMen_US
dc.contributor.authorEjlertsen, Ben_US
dc.contributor.authorEllberg, Cen_US
dc.contributor.authorEngel, Cen_US
dc.contributor.authorEriksson, Men_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorFletcher, Oen_US
dc.contributor.authorFlyger, Hen_US
dc.contributor.authorFriedman, Een_US
dc.contributor.authorFrost, Den_US
dc.contributor.authorGabrielson, Men_US
dc.contributor.authorGago-Dominguez, Men_US
dc.contributor.authorGanz, PAen_US
dc.contributor.authorGapstur, SMen_US
dc.contributor.authorGarber, Jen_US
dc.contributor.authorGarcía-Closas, Men_US
dc.contributor.authorGarcía-Sáenz, JAen_US
dc.contributor.authorGaudet, MMen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGlendon, Gen_US
dc.contributor.authorGodwin, AKen_US
dc.contributor.authorGoldberg, MSen_US
dc.contributor.authorGoldgar, DEen_US
dc.contributor.authorGonzález-Neira, Aen_US
dc.contributor.authorGreene, MHen_US
dc.contributor.authorGronwald, Jen_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorHe, Wen_US
dc.contributor.authorHeyworth, Jen_US
dc.contributor.authorHogervorst, FBLen_US
dc.contributor.authorHollestelle, Aen_US
dc.contributor.authorHoover, RNen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorHulick, PJen_US
dc.contributor.authorHumphreys, Ken_US
dc.contributor.authorImyanitov, ENen_US
dc.contributor.authorABCTB Investigatorsen_US
dc.contributor.authorHEBON Investigatorsen_US
dc.contributor.authorBCFR Investigatorsen_US
dc.contributor.authorIsaacs, Cen_US
dc.contributor.authorJakimovska, Men_US
dc.contributor.authorJakubowska, Aen_US
dc.contributor.authorJames, PAen_US
dc.contributor.authorJanavicius, Ren_US
dc.contributor.authorJankowitz, RCen_US
dc.contributor.authorJohn, EMen_US
dc.contributor.authorJohnson, Nen_US
dc.contributor.authorJoseph, Ven_US
dc.contributor.authorKarlan, BYen_US
dc.contributor.authorKhusnutdinova, Een_US
dc.contributor.authorKiiski, JIen_US
dc.contributor.authorKo, Y-Den_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorKonstantopoulou, Ien_US
dc.contributor.authorKristensen, VNen_US
dc.contributor.authorLaitman, Yen_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorLazaro, Cen_US
dc.contributor.authorLeslie, Gen_US
dc.contributor.authorLester, Jen_US
dc.contributor.authorLesueur, Fen_US
dc.contributor.authorLindström, Sen_US
dc.contributor.authorLong, Jen_US
dc.contributor.authorLoud, JTen_US
dc.contributor.authorLubiński, Jen_US
dc.contributor.authorMakalic, Een_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorManoochehri, Men_US
dc.contributor.authorMargolin, Sen_US
dc.contributor.authorMaurer, Ten_US
dc.contributor.authorMavroudis, Den_US
dc.contributor.authorMcGuffog, Len_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorMenon, Uen_US
dc.contributor.authorMichailidou, Ken_US
dc.contributor.authorMiller, Aen_US
dc.contributor.authorMontagna, Men_US
dc.contributor.authorMoreno, Fen_US
dc.contributor.authorMoserle, Len_US
dc.contributor.authorMulligan, AMen_US
dc.contributor.authorNathanson, KLen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorNevelsteen, Ien_US
dc.contributor.authorNielsen, FCen_US
dc.contributor.authorNikitina-Zake, Len_US
dc.contributor.authorNussbaum, RLen_US
dc.contributor.authorOffit, Ken_US
dc.contributor.authorOlah, Een_US
dc.contributor.authorOlopade, OIen_US
dc.contributor.authorOlsson, Hen_US
dc.contributor.authorOsorio, Aen_US
dc.contributor.authorPapp, Jen_US
dc.contributor.authorPark-Simon, T-Wen_US
dc.contributor.authorParsons, MTen_US
dc.contributor.authorPedersen, ISen_US
dc.contributor.authorPeixoto, Aen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorPharoah, PDPen_US
dc.contributor.authorPlaseska-Karanfilska, Den_US
dc.contributor.authorPoppe, Ben_US
dc.contributor.authorPresneau, Nen_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorRantala, Jen_US
dc.contributor.authorRennert, Gen_US
dc.contributor.authorRisch, HAen_US
dc.contributor.authorSaloustros, Een_US
dc.contributor.authorSanden, Ken_US
dc.contributor.authorSawyer, EJen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorSharma, Pen_US
dc.contributor.authorShu, X-Oen_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorSinger, CFen_US
dc.contributor.authorSoucy, Pen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorSpinelli, JJen_US
dc.contributor.authorSpurdle, ABen_US
dc.contributor.authorStone, Jen_US
dc.contributor.authorSwerdlow, AJen_US
dc.contributor.authorTapper, WJen_US
dc.contributor.authorTaylor, JAen_US
dc.contributor.authorTeixeira, MRen_US
dc.contributor.authorTerry, MBen_US
dc.contributor.authorTeulé, Aen_US
dc.contributor.authorThomassen, Men_US
dc.contributor.authorThöne, Ken_US
dc.contributor.authorThull, DLen_US
dc.contributor.authorTischkowitz, Men_US
dc.contributor.authorToland, AEen_US
dc.contributor.authorTorres, Den_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorTung, Nen_US
dc.contributor.authorVachon, CMen_US
dc.contributor.authorvan Asperen, CJen_US
dc.contributor.authorvan den Ouweland, AMWen_US
dc.contributor.authorvan Rensburg, EJen_US
dc.contributor.authorVega, Aen_US
dc.contributor.authorViel, Aen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorWappenschmidt, Ben_US
dc.contributor.authorWeitzel, JNen_US
dc.contributor.authorWendt, Cen_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorYang, XRen_US
dc.contributor.authorYannoukakos, Den_US
dc.contributor.authorZiogas, Aen_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorAntoniou, ACen_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorBeesley, Jen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-07-05T13:42:05Z
dc.date.issued2019-04-15en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30988301en_US
dc.identifier10.1038/s41467-018-08053-5en_US
dc.identifier.citationNat Commun, 2019, 10 (1), pp. 1741 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3284
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/s41467-018-08053-5en_US
dc.description.abstractGenome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.en_US
dc.format.extent1741 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBreast Neoplasmsen_US
dc.subjectFemaleen_US
dc.subjectGene Expression Profilingen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenome-Wide Association Studyen_US
dc.subjectHumansen_US
dc.subjectQuantitative Trait Locien_US
dc.titleGenome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-12-14en_US
rioxxterms.versionofrecord10.1038/s41467-018-08053-5en_US
rioxxterms.licenseref.startdate2019-04-15en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNat Communen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished onlineen_US
pubs.volume10en_US
pubs.embargo.termsNot knownen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorFletcher, Oliviaen_US
dc.contributor.icrauthorJones, Michaelen_US


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