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dc.contributor.authorSaunders, CN
dc.contributor.authorCornish, AJ
dc.contributor.authorKinnersley, B
dc.contributor.authorLaw, PJ
dc.contributor.authorClaus, EB
dc.contributor.authorIl'yasova, D
dc.contributor.authorSchildkraut, J
dc.contributor.authorBarnholtz-Sloan, JS
dc.contributor.authorOlson, SH
dc.contributor.authorBernstein, JL
dc.contributor.authorLai, RK
dc.contributor.authorChanock, S
dc.contributor.authorRajaraman, P
dc.contributor.authorJohansen, C
dc.contributor.authorJenkins, RB
dc.contributor.authorMelin, BS
dc.contributor.authorWrensch, MR
dc.contributor.authorSanson, M
dc.contributor.authorBondy, ML
dc.contributor.authorHoulston, RS
dc.date.accessioned2019-11-01T10:06:47Z
dc.date.issued2020-02
dc.identifier.citationNeuro-oncology, 2020, 22 (2), pp. 207 - 215
dc.identifier.issn1522-8517
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3396
dc.identifier.eissn1523-5866
dc.identifier.doi10.1093/neuonc/noz209
dc.description.abstractBackground The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian randomization (MR) framework to examine if lifestyle, cardiometabolic, and inflammatory factors influence the risk of glioma. This methodology reduces bias from confounding and is not affected by reverse causation.Methods We identified genetic instruments for 37 potentially modifiable risk factors and evaluated their association with glioma risk using data from a genome-wide association study of 12 488 glioma patients and 18 169 controls. We used the estimated odds ratio of glioma associated with each of the genetically defined traits to infer evidence for a causal relationship with the following exposures:Lifestyle and dietary factors-height, plasma insulin-like growth factor 1, blood carnitine, blood methionine, blood selenium, blood zinc, circulating adiponectin, circulating carotenoids, iron status, serum calcium, vitamins (A1, B12, B6, E, and 25-hydroxyvitamin D), fatty acid levels (monounsaturated, omega-3, and omega-6) and circulating fetuin-A;Cardiometabolic factors-birth weight, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, total triglycerides, basal metabolic rate, body fat percentage, body mass index, fasting glucose, fasting proinsulin, glycated hemoglobin levels, diastolic and systolic blood pressure, waist circumference, waist-to-hip ratio; andInflammatory factors- C-reactive protein, plasma interleukin-6 receptor subunit alpha and serum immunoglobulin E.Results After correction for the testing of multiple potential risk factors and excluding associations driven by one single nucleotide polymorphism, no significant association with glioma risk was observed (ie, PCorrected > 0.05).Conclusions This study did not provide evidence supporting any of the 37 factors examined as having a significant influence on glioma risk.
dc.formatPrint
dc.format.extent207 - 215
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleLack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis.
dc.typeJournal Article
dcterms.dateAccepted2019-10-21
rioxxterms.versionofrecord10.1093/neuonc/noz209
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNeuro-oncology
pubs.issue2
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume22
pubs.embargo.termsNo embargo
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorSaunders, Charlesen
dc.contributor.icrauthorLaw, Philipen
dc.contributor.icrauthorKinnersley, Benjaminen


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