Class(y) Dissection of <i>BRAF</i> Heterogeneity: Beyond Non-V600.

Abstract

Different classes of <i>BRAF</i> mutations are present in colorectal and other cancers. Non-V600 mutations are rare; however, their detection rate will increase as the use of next-generation sequencing ramps up quickly in clinical practice. Different biochemical signaling pathways are active in non-V600 <i>BRAF</i>-mutant cancers and may affect treatment response.<i>See related article by Yaeger et al., p. 7089</i>.