Class(y) Dissection of BRAF Heterogeneity: Beyond Non-V600.
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Different classes of BRAF mutations are present in colorectal and other cancers. Non-V600 mutations are rare; however, their detection rate will increase as the use of next-generation sequencing ramps up quickly in clinical practice. Different biochemical signaling pathways are active in non-V600 BRAF-mutant cancers and may affect treatment response.See related article by Yaeger et al., p. 7089.
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Gastrointestinal Cancer Biology and Genomics
Systems and Precision Cancer Medicine
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Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 25 (23), pp. 6896 - 6898