Class(y) Dissection of <i>BRAF</i> Heterogeneity: Beyond Non-V600.
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Different classes of <i>BRAF</i> mutations are present in colorectal and other cancers. Non-V600 mutations are rare; however, their detection rate will increase as the use of next-generation sequencing ramps up quickly in clinical practice. Different biochemical signaling pathways are active in non-V600 <i>BRAF</i>-mutant cancers and may affect treatment response.<i>See related article by Yaeger et al., p. 7089</i>.
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Proto-Oncogene Proteins B-raf
Gastrointestinal Cancer Biology and Genomics
Systems and Precision Cancer Medicine
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Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 25 (23), pp. 6896 - 6898