Publications Repository

Publications Repository

View Item 
  •   Home
  • ICR Divisions
  • Radiotherapy and Imaging
  • View Item
  • Home
  • ICR Divisions
  • Radiotherapy and Imaging
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Radiomic features of cervical cancer on T2-and diffusion-weighted MRI: Prognostic value in low-volume tumors suitable for trachelectomy.

Thumbnail
View/Open
Accepted version (1.113Mb)
Publication Date
2020-01
ICR Author
Doran, Simon
deSouza, Nandita
Author
Wormald, BW
Doran, SJ
Ind, TE
D'Arcy, J
Petts, J
deSouza, NM
Type
Journal Article
Metadata
Show full item record
Abstract
<h4>Background</h4>Textural features extracted from MRI potentially provide prognostic information additional to volume for influencing surgical management of cervical cancer.<h4>Purpose</h4>To identify textural features that differ between cervical tumors above and below the volume threshold of eligibility for trachelectomy and determine their value in predicting recurrence in patients with low-volume tumors.<h4>Methods</h4>Of 378 patients with Stage1-2 cervical cancer imaged prospectively (3T, endovaginal coil), 125 had well-defined, histologically-confirmed squamous or adenocarcinomas with >100 voxels (>0.07 cm<sup>3</sup>) suitable for radiomic analysis. Regions-of-interest outlined the whole tumor on T2-W images and apparent diffusion coefficient (ADC) maps. Textural features based on grey-level co-occurrence matrices were compared (Mann-Whitney test with Bonferroni correction) between tumors greater (n = 46) or less (n = 79) than 4.19 cm<sup>3</sup>. Clustering eliminated correlated variables. Significantly different features were used to predict recurrence (regression modelling) in surgically-treated patients with low-volume tumors and compared with a model using clinico-pathological features.<h4>Results</h4>Textural features (Dissimilarity, Energy, ClusterProminence, ClusterShade, InverseVariance, Autocorrelation) in 6 of 10 clusters from T2-W and ADC data differed between high-volume (mean ± SD 15.3 ± 11.7 cm<sup>3</sup>) and low-volume (mean ± SD 1.3 ± 1.2 cm<sup>3</sup>) tumors. (p < 0.02). In low-volume tumors, predicting recurrence was indicated by: Dissimilarity, Energy (ADC-radiomics, AUC = 0.864); Dissimilarity, ClusterProminence, InverseVariance (T2-W-radiomics, AUC = 0.808); Volume, Depth of Invasion, LymphoVascular Space Invasion (clinico-pathological features, AUC = 0.794). Combining ADC-radiomic (but not T2-radiomic) and clinico-pathological features improved prediction of recurrence compared to the clinico-pathological model (AUC = 0.916, p = 0.006). Findings were supported by bootstrap re-sampling (n = 1000).<h4>Conclusion</h4>Textural features from ADC maps and T2-W images differ between high- and low-volume tumors and potentially predict recurrence in low-volume tumors.
URL
https://repository.icr.ac.uk/handle/internal/3429
Collections
  • Radiotherapy and Imaging
Licenseref URL
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Version of record
10.1016/j.ygyno.2019.10.010
Subject
Humans
Diffusion Magnetic Resonance Imaging
Neoplasm Staging
Prognosis
Tumor Burden
Logistic Models
Prospective Studies
Pilot Projects
Adult
Aged
Aged, 80 and over
Middle Aged
Uterine Cervical Neoplasms
Female
Young Adult
Trachelectomy
Research team
Magnetic Resonance
Language
eng
Date accepted
2019-10-08
License start date
2020-01
Citation
Gynecologic oncology, 2020, 156 (1), pp. 107 - 114

Browse

All of ICR repositoryICR DivisionsIssue dateAuthorsTitlesSubjectsThis collectionIssue dateAuthorsTitlesSubjects

Statistics

Most popular itemsStatistics by countryMost popular authors
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.