Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.
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Date
2019-07-03Author
Chamberlain, FE
Wilding, C
Jones, RL
Huang, P
Type
Journal Article
Metadata
Show full item recordAbstract
Introduction: Liposarcomas (LPS) are a heterogeneous group of adipocytic soft tissue sarcomas with limited treatment options in the advanced/metastatic setting. Pazopanib is a multi-target tyrosine kinase inhibitor (TKI) with anti-angiogenic and antitumorigenic properties. Whilst targeted agents including TKIs have been extensively studied in other solid tumors and the sarcoma subtype gastrointestinal stromal tumor (GIST), we currently lack effective treatments for the liposarcoma subtype. Several phase II and III studies of oral TKIs in soft tissue sarcomas have excluded liposarcoma because of a reported lack of activity following the EORTC 62043 study. Areas: We review the use of pazopanib in advanced intermediate and high-grade liposarcomas where complete surgical resection is not possible. Expert opinion: The current clinical and pharmacological data demonstrate the efficacy of pazopanib in soft tissue sarcomas, but new data suggest that anti-angiogenic agents may have limited activity in liposarcoma. Anti-angiogenic TKIs are generally well tolerated and liposarcomas vary in their response to systemic chemotherapy; hence, there is a role for further exploration of the efficacy of this treatment amongst the histological subtypes of liposarcoma. This affords further understanding of biomarkers which may be associated with response to pazopanib and other anti-angiogenic TKI treatments.
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Subject
Animals
Humans
Liposarcoma
Sulfonamides
Pyrimidines
Angiogenesis Inhibitors
Protein Kinase Inhibitors
Treatment Outcome
Neoplasm Grading
Biomarkers, Tumor
Research team
Sarcoma Clinical Trials (R Jones)
Molecular and Systems Oncology
Language
eng
License start date
2019-06
Citation
Expert opinion on investigational drugs, 2019, 28 (6), pp. 505 - 511
Publisher
TAYLOR & FRANCIS LTD