dc.contributor.author | Brüningk, SC | |
dc.contributor.author | Rivens, I | |
dc.contributor.author | Mouratidis, P | |
dc.contributor.author | Ter Haar, G | |
dc.date.accessioned | 2020-01-08T13:52:49Z | |
dc.date.issued | 2019-12-01 | |
dc.identifier.citation | Ultrasound in medicine & biology, 2019, 45 (12), pp. 3290 - 3297 | |
dc.identifier.issn | 0301-5629 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3485 | |
dc.identifier.eissn | 1879-291X | |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2019.06.410 | |
dc.description.abstract | An experimental arrangement that allows in vitro exposure of cells to focused ultrasound-mediated hyperthermia (43°C-55°C) in a tissue-mimicking phantom with biological, acoustic and thermal properties comparable to those of human soft tissue is described. Cells were embedded in a compressed collagen gel, which was sandwiched between 6-mm-thick slices of biocompatible, acoustically absorbing and thermally tissue mimicking poly(vinyl alcohol) cryo-gel. To illustrate the system's potential, cells were exposed using a 1.66-MHz focused ultrasound beam (spatial-peak temporal-average intensities (ISPTA) = 900-1400 W/cm2) that traced out a circular trajectory (5-8 mm in diameter). Real-time temperature monitoring allowed cells to be exposed reproducibly to a pre-determined thermal dose. An experimental planning tool that estimates the thermal dose distribution throughout the sample and allows spatial correlation with cell position has been developed. Treatment response was evaluated qualitatively using microscopy and cell viability testing. This experimental arrangement has significant potential for future, biologically relevant, in vitro focused ultrasound-mediated hyperthermia studies. | |
dc.format | Print-Electronic | |
dc.format.extent | 3290 - 3297 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Hyperthermia, Induced | |
dc.subject | Phantoms, Imaging | |
dc.subject | High-Intensity Focused Ultrasound Ablation | |
dc.subject | In Vitro Techniques | |
dc.title | Focused Ultrasound-Mediated Hyperthermia in Vitro: An Experimental Arrangement for Treating Cells under Tissue-Mimicking Conditions. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-06-18 | |
rioxxterms.versionofrecord | 10.1016/j.ultrasmedbio.2019.06.410 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.licenseref.startdate | 2019-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Ultrasound in medicine & biology | |
pubs.issue | 12 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound | |
pubs.publication-status | Published | |
pubs.volume | 45 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Radiotherapy Physics Modelling | |
icr.researchteam | Therapeutic Ultrasound | |
dc.contributor.icrauthor | Rivens, Ian | |
dc.contributor.icrauthor | Mouratidis, Petros | |
dc.contributor.icrauthor | Ter Haar, Gail | |