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dc.contributor.authorBrüningk, SCen_US
dc.contributor.authorRivens, Ien_US
dc.contributor.authorMouratidis, Pen_US
dc.contributor.authorTer Haar, Gen_US
dc.date.accessioned2020-01-08T13:52:49Z
dc.date.issued2019-12en_US
dc.identifier.citationUltrasound in medicine & biology, 2019, 45 (12), pp. 3290 - 3297en_US
dc.identifier.issn0301-5629en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3485
dc.identifier.eissn1879-291Xen_US
dc.identifier.doi10.1016/j.ultrasmedbio.2019.06.410en_US
dc.description.abstractAn experimental arrangement that allows in vitro exposure of cells to focused ultrasound-mediated hyperthermia (43°C-55°C) in a tissue-mimicking phantom with biological, acoustic and thermal properties comparable to those of human soft tissue is described. Cells were embedded in a compressed collagen gel, which was sandwiched between 6-mm-thick slices of biocompatible, acoustically absorbing and thermally tissue mimicking poly(vinyl alcohol) cryo-gel. To illustrate the system's potential, cells were exposed using a 1.66-MHz focused ultrasound beam (spatial-peak temporal-average intensities (ISPTA) = 900-1400 W/cm2) that traced out a circular trajectory (5-8 mm in diameter). Real-time temperature monitoring allowed cells to be exposed reproducibly to a pre-determined thermal dose. An experimental planning tool that estimates the thermal dose distribution throughout the sample and allows spatial correlation with cell position has been developed. Treatment response was evaluated qualitatively using microscopy and cell viability testing. This experimental arrangement has significant potential for future, biologically relevant, in vitro focused ultrasound-mediated hyperthermia studies.en_US
dc.formatPrint-Electronicen_US
dc.format.extent3290 - 3297en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.titleFocused Ultrasound-Mediated Hyperthermia in Vitro: An Experimental Arrangement for Treating Cells under Tissue-Mimicking Conditions.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-06-18en_US
rioxxterms.versionofrecord10.1016/j.ultrasmedbio.2019.06.410en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
rioxxterms.licenseref.startdate2019-12en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfUltrasound in medicine & biologyen_US
pubs.issue12en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.publication-statusPublisheden_US
pubs.volume45en_US
pubs.embargo.termsNot knownen_US
icr.researchteamRadiotherapy Physics Modellingen_US
icr.researchteamTherapeutic Ultrasounden_US
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthorRivens, Ianen_US
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthorBrueningk, Sarahen_US


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0