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dc.contributor.authorSedgwick, AC
dc.contributor.authorBrewster, JT
dc.contributor.authorHarvey, P
dc.contributor.authorIovan, DA
dc.contributor.authorSmith, G
dc.contributor.authorHe, X-P
dc.contributor.authorTian, H
dc.contributor.authorSessler, JL
dc.contributor.authorJames, TD
dc.date.accessioned2020-04-02T10:29:41Z
dc.date.issued2020-05
dc.identifier.citationChemical Society reviews, 2020, 49 (10), pp. 2886 - 2915
dc.identifier.issn0306-0012
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3570
dc.identifier.eissn1460-4744
dc.identifier.doi10.1039/c8cs00986d
dc.description.abstractCentral nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of the malfunctions underpinning disease progression will prove requisite in developing new treatments and cures. Transition metals and lanthanide ions display unique characteristics (i.e., magnetism, radioactivity, and luminescence), often with biological relevance, allowing for direct application in CNS focused imaging modalities. These techniques include positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and luminescent-based imaging (LumI). In this Tutorial Review, we have aimed to highlight the various metal-based imaging techniques developed in the effort to understand the pathophysiological processes associated with neurodegeneration. Each section has been divided so as to include an introduction to the particular imaging technique in question. This is then followed by a summary of key demonstrations that have enabled visualization of a specific neuropathological biomarker. These strategies have either exploited the high binding affinity of a receptor for its corresponding biomarker or a specific molecular transformation caused by a target species, all of which produce a concomitant change in diagnostic signal. Advantages and disadvantages of each method with perspectives on the utility of molecular imaging agents for understanding the complexities of neurodegenerative disease are discussed.
dc.formatPrint-Electronic
dc.format.extent2886 - 2915
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeurodegenerative Diseases
dc.subjectTransition Elements
dc.subjectMetals
dc.subjectIndicators and Reagents
dc.subjectPositron-Emission Tomography
dc.subjectTomography, Emission-Computed, Single-Photon
dc.subjectMagnetic Resonance Imaging
dc.subjectCoordination Complexes
dc.titleMetal-based imaging agents: progress towards interrogating neurodegenerative disease.
dc.typeJournal Article
rioxxterms.versionofrecord10.1039/c8cs00986d
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfChemical Society reviews
pubs.issue10
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/PET Radiochemistry
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/PET Radiochemistry
pubs.publication-statusPublished
pubs.volume49
pubs.embargo.termsNot known
icr.researchteamPET Radiochemistryen_US
dc.contributor.icrauthorSmith, Grahamen


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