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dc.contributor.authorJackman, M
dc.contributor.authorMarcozzi, C
dc.contributor.authorBarbiero, M
dc.contributor.authorPardo, M
dc.contributor.authorYu, L
dc.contributor.authorTyson, AL
dc.contributor.authorChoudhary, JS
dc.contributor.authorPines, J
dc.date.accessioned2020-05-18T10:20:27Z
dc.date.issued2020-06-01
dc.identifier.citationThe Journal of cell biology, 2020, 219 (6)
dc.identifier.issn0021-9525
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3608
dc.identifier.eissn1540-8140
dc.identifier.doi10.1083/jcb.201907082
dc.description.abstractHow the cell rapidly and completely reorganizes its architecture when it divides is a problem that has fascinated researchers for almost 150 yr. We now know that the core regulatory machinery is highly conserved in eukaryotes, but how these multiple protein kinases, protein phosphatases, and ubiquitin ligases are coordinated in space and time to remodel the cell in a matter of minutes remains a major question. Cyclin B1-Cdk is the primary kinase that drives mitotic remodeling; here we show that it is targeted to the nuclear pore complex (NPC) by binding an acidic face of the kinetochore checkpoint protein, MAD1, where it coordinates NPC disassembly with kinetochore assembly. Localized cyclin B1-Cdk1 is needed for the proper release of MAD1 from the embrace of TPR at the nuclear pore so that it can be recruited to kinetochores before nuclear envelope breakdown to maintain genomic stability.
dc.formatPrint
dc.languageeng
dc.language.isoeng
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint.
dc.typeJournal Article
dcterms.dateAccepted2020-03-06
rioxxterms.versionofrecord10.1083/jcb.201907082
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfThe Journal of cell biology
pubs.issue6
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group
pubs.publication-statusPublished
pubs.volume219
pubs.embargo.termsNot known
icr.researchteamFunctional Proteomics Group
dc.contributor.icrauthorPardo Calvo, Maria Mercedes
dc.contributor.icrauthorChoudhary, Jyoti
dc.contributor.icrauthorPines, Jonathon


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