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dc.contributor.authorKapoor, PM
dc.contributor.authorMavaddat, N
dc.contributor.authorChoudhury, PP
dc.contributor.authorWilcox, AN
dc.contributor.authorLindström, S
dc.contributor.authorBehrens, S
dc.contributor.authorMichailidou, K
dc.contributor.authorDennis, J
dc.contributor.authorBolla, MK
dc.contributor.authorWang, Q
dc.contributor.authorJung, A
dc.contributor.authorAbu-Ful, Z
dc.contributor.authorAhearn, T
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArndt, V
dc.contributor.authorAronson, KJ
dc.contributor.authorAuer, PL
dc.contributor.authorFreeman, LEB
dc.contributor.authorBecher, H
dc.contributor.authorBeckmann, MW
dc.contributor.authorBeeghly-Fadiel, A
dc.contributor.authorBenitez, J
dc.contributor.authorBernstein, L
dc.contributor.authorBojesen, SE
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrüning, T
dc.contributor.authorCai, Q
dc.contributor.authorCampa, D
dc.contributor.authorCanzian, F
dc.contributor.authorCarracedo, A
dc.contributor.authorCarter, BD
dc.contributor.authorCastelao, JE
dc.contributor.authorChanock, SJ
dc.contributor.authorChatterjee, N
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorClarke, CL
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDai, JY
dc.contributor.authorEarp, HS
dc.contributor.authorEkici, AB
dc.contributor.authorEliassen, AH
dc.contributor.authorEriksson, M
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFritschi, L
dc.contributor.authorGabrielson, M
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGao, C
dc.contributor.authorGapstur, SM
dc.contributor.authorGaudet, MM
dc.contributor.authorGiles, GG
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorGuénel, P
dc.contributor.authorHaeberle, L
dc.contributor.authorHaiman, CA
dc.contributor.authorHåkansson, N
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHatse, S
dc.contributor.authorHeyworth, J
dc.contributor.authorHolleczek, B
dc.contributor.authorHoover, RN
dc.contributor.authorHopper, JL
dc.contributor.authorHowell, A
dc.contributor.authorHunter, DJ
dc.contributor.authorABCTB Investigators
dc.contributor.authorkConFab/AOCS Investigators
dc.contributor.authorJohn, EM
dc.contributor.authorJones, ME
dc.contributor.authorKaaks, R
dc.contributor.authorKeeman, R
dc.contributor.authorKitahara, CM
dc.contributor.authorKo, Y-D
dc.contributor.authorKoutros, S
dc.contributor.authorKurian, AW
dc.contributor.authorLambrechts, D
dc.contributor.authorMarchand, LL
dc.contributor.authorLee, E
dc.contributor.authorLejbkowicz, F
dc.contributor.authorLinet, M
dc.contributor.authorLissowska, J
dc.contributor.authorLlaneza, A
dc.contributor.authorMacInnis, RJ
dc.contributor.authorMartinez, ME
dc.contributor.authorMaurer, T
dc.contributor.authorMcLean, C
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNewman, WG
dc.contributor.authorNorman, A
dc.contributor.authorO'Brien, KM
dc.contributor.authorOlshan, AF
dc.contributor.authorOlson, JE
dc.contributor.authorOlsson, H
dc.contributor.authorOrr, N
dc.contributor.authorPerou, CM
dc.contributor.authorPita, G
dc.contributor.authorPolley, EC
dc.contributor.authorPrentice, RL
dc.contributor.authorRennert, G
dc.contributor.authorRennert, HS
dc.contributor.authorRuddy, KJ
dc.contributor.authorSandler, DP
dc.contributor.authorSaunders, C
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorSchöttker, B
dc.contributor.authorSchumacher, F
dc.contributor.authorScott, C
dc.contributor.authorScott, RJ
dc.contributor.authorShu, X-O
dc.contributor.authorSmeets, A
dc.contributor.authorSouthey, MC
dc.contributor.authorSpinelli, JJ
dc.contributor.authorStone, J
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTamimi, RM
dc.contributor.authorTaylor, JA
dc.contributor.authorTroester, MA
dc.contributor.authorVachon, CM
dc.contributor.authorvan Veen, EM
dc.contributor.authorWang, X
dc.contributor.authorWeinberg, CR
dc.contributor.authorWeltens, C
dc.contributor.authorWillett, W
dc.contributor.authorWinham, SJ
dc.contributor.authorWolk, A
dc.contributor.authorYang, XR
dc.contributor.authorZheng, W
dc.contributor.authorZiogas, A
dc.contributor.authorDunning, AM
dc.contributor.authorPharoah, PDP
dc.contributor.authorSchmidt, MK
dc.contributor.authorKraft, P
dc.contributor.authorEaston, DF
dc.contributor.authorMilne, RL
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorChang-Claude, J
dc.date.accessioned2020-05-18T14:25:37Z
dc.date.issued2020-05-02
dc.identifier.citationJournal of the National Cancer Institute, 2020
dc.identifier.issn0027-8874
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3614
dc.identifier.eissn1460-2105
dc.identifier.doi10.1093/jnci/djaa056
dc.description.abstractWe evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
dc.formatPrint-Electronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.subjectABCTB Investigators
dc.subjectkConFab/AOCS Investigators
dc.titleCombined associations of a polygenic risk score and classical risk factors with breast cancer risk.
dc.typeJournal Article
dcterms.dateAccepted2020-04-06
rioxxterms.versionofrecord10.1093/jnci/djaa056
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0
rioxxterms.licenseref.startdate2020-05-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJournal of the National Cancer Institute
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.embargo.termsNot known
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorOrr, Nicholasen
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorSchoemaker, Minouken
dc.contributor.icrauthorJones, Michaelen


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