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dc.contributor.authorKapoor, PMen_US
dc.contributor.authorMavaddat, Nen_US
dc.contributor.authorChoudhury, PPen_US
dc.contributor.authorWilcox, ANen_US
dc.contributor.authorLindström, Sen_US
dc.contributor.authorBehrens, Sen_US
dc.contributor.authorMichailidou, Ken_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorJung, Aen_US
dc.contributor.authorAbu-Ful, Zen_US
dc.contributor.authorAhearn, Ten_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorAronson, KJen_US
dc.contributor.authorAuer, PLen_US
dc.contributor.authorFreeman, LEBen_US
dc.contributor.authorBecher, Hen_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBeeghly-Fadiel, Aen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBernstein, Len_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorBrüning, Ten_US
dc.contributor.authorCai, Qen_US
dc.contributor.authorCampa, Den_US
dc.contributor.authorCanzian, Fen_US
dc.contributor.authorCarracedo, Aen_US
dc.contributor.authorCarter, BDen_US
dc.contributor.authorCastelao, JEen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorChatterjee, Nen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorClarke, CLen_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorDai, JYen_US
dc.contributor.authorEarp, HSen_US
dc.contributor.authorEkici, ABen_US
dc.contributor.authorEliassen, AHen_US
dc.contributor.authorEriksson, Men_US
dc.contributor.authorEvans, DGen_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorFritschi, Len_US
dc.contributor.authorGabrielson, Men_US
dc.contributor.authorGago-Dominguez, Men_US
dc.contributor.authorGao, Cen_US
dc.contributor.authorGapstur, SMen_US
dc.contributor.authorGaudet, MMen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGonzález-Neira, Aen_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorHaeberle, Len_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorHåkansson, Nen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorHatse, Sen_US
dc.contributor.authorHeyworth, Jen_US
dc.contributor.authorHolleczek, Ben_US
dc.contributor.authorHoover, RNen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorHowell, Aen_US
dc.contributor.authorHunter, DJen_US
dc.contributor.authorABCTB Investigatorsen_US
dc.contributor.authorkConFab/AOCS Investigatorsen_US
dc.contributor.authorJohn, EMen_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorKaaks, Ren_US
dc.contributor.authorKeeman, Ren_US
dc.contributor.authorKitahara, CMen_US
dc.contributor.authorKo, Y-Den_US
dc.contributor.authorKoutros, Sen_US
dc.contributor.authorKurian, AWen_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorMarchand, LLen_US
dc.contributor.authorLee, Een_US
dc.contributor.authorLejbkowicz, Fen_US
dc.contributor.authorLinet, Men_US
dc.contributor.authorLissowska, Jen_US
dc.contributor.authorLlaneza, Aen_US
dc.contributor.authorMacInnis, RJen_US
dc.contributor.authorMartinez, MEen_US
dc.contributor.authorMaurer, Ten_US
dc.contributor.authorMcLean, Cen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorNewman, WGen_US
dc.contributor.authorNorman, Aen_US
dc.contributor.authorO'Brien, KMen_US
dc.contributor.authorOlshan, AFen_US
dc.contributor.authorOlson, JEen_US
dc.contributor.authorOlsson, Hen_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorPerou, CMen_US
dc.contributor.authorPita, Gen_US
dc.contributor.authorPolley, ECen_US
dc.contributor.authorPrentice, RLen_US
dc.contributor.authorRennert, Gen_US
dc.contributor.authorRennert, HSen_US
dc.contributor.authorRuddy, KJen_US
dc.contributor.authorSandler, DPen_US
dc.contributor.authorSaunders, Cen_US
dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorSchöttker, Ben_US
dc.contributor.authorSchumacher, Fen_US
dc.contributor.authorScott, Cen_US
dc.contributor.authorScott, RJen_US
dc.contributor.authorShu, X-Oen_US
dc.contributor.authorSmeets, Aen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorSpinelli, JJen_US
dc.contributor.authorStone, Jen_US
dc.contributor.authorSwerdlow, AJen_US
dc.contributor.authorTamimi, RMen_US
dc.contributor.authorTaylor, JAen_US
dc.contributor.authorTroester, MAen_US
dc.contributor.authorVachon, CMen_US
dc.contributor.authorvan Veen, EMen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorWeinberg, CRen_US
dc.contributor.authorWeltens, Cen_US
dc.contributor.authorWillett, Wen_US
dc.contributor.authorWinham, SJen_US
dc.contributor.authorWolk, Aen_US
dc.contributor.authorYang, XRen_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorZiogas, Aen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorPharoah, PDPen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorGarcía-Closas, Men_US
dc.contributor.authorChang-Claude, Jen_US
dc.date.accessioned2020-05-18T14:25:37Z
dc.date.issued2020-05-02en_US
dc.identifier.citationJournal of the National Cancer Institute, 2020en_US
dc.identifier.issn0027-8874en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3614
dc.identifier.eissn1460-2105en_US
dc.identifier.doi10.1093/jnci/djaa056en_US
dc.description.abstractWe evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.en_US
dc.formatPrint-Electronicen_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.subjectABCTB Investigatorsen_US
dc.subjectkConFab/AOCS Investigatorsen_US
dc.titleCombined associations of a polygenic risk score and classical risk factors with breast cancer risk.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-04-06en_US
rioxxterms.versionofrecord10.1093/jnci/djaa056en_US
rioxxterms.licenseref.startdate2020-05-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfJournal of the National Cancer Instituteen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublisheden_US
pubs.embargo.termsNot knownen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorSchoemaker, Minouken_US


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