Mean heart dose variation over a course of breath-holding breast cancer radiotherapy.
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Date
2016-11ICR Author
Author
Dunkerley, N
Bartlett, FR
Kirby, AM
Evans, PM
Donovan, EM
Type
Journal Article
Metadata
Show full item recordAbstract
Objective The purpose of the work was to estimate the dose received by the heart throughout a course of breath-holding breast radiotherapy.Methods 113 cone-beam CT (CBCT) scans were acquired for 20 patients treated within the HeartSpare 1A study, in which both an active breathing control (ABC) device and a voluntary breath-hold (VBH) method were used. Predicted mean heart doses were obtained from treatment plans. CBCT scans were imported into a treatment planning system, heart outlines defined, images registered to the CT planning scan and mean heart dose recorded. Two observers outlined two cases three times each to assess interobserver and intraobserver variation.Results There were no statistically significant differences between ABC and VBH heart dose data from CT planning scans, or in the CBCT-based estimates of heart dose, and no effect from the order of the breath-hold method. Variation in mean heart dose per fraction over the three imaged fractions was <6 cGy without setup correction, decreasing to 3.3 cGy with setup correction. If scaled to 15 fractions, all differences between predicted and estimated mean heart doses were <0.5 Gy and in 80% of cases, they were <0.25 Gy.Conclusion Variation in mean heart dose was at an acceptable level over the duration of breath-holding radiotherapy and was well predicted by the planning system. Advances in knowledge: Mean heart dose was not adversely affected by fraction-to-fraction variations throughout a course of heart-sparing radiotherapy using two well-established breath-holding methods.
Collections
Subject
Heart
Humans
Breast Neoplasms
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Female
Cone-Beam Computed Tomography
Radiotherapy, Image-Guided
Breath Holding
Research team
Breast Cancer Radiotherapy
Language
eng
License start date
2016-11
Citation
The British journal of radiology, 2016, 89 (1067), pp. 20160536 - ?